loosely bound state in the MSM suggest we are simulating an encounter complex. In the future, we plan to look at the binding pathway of ArkA17, which has extended C and N-terminal ends. We use coarse grained Langevin dynamics simulations to study the effect of the capsid tail in packing of semiflexible polymers into a spherical capsid inside a crowded cell. Such packing conditions are relevant, for example, to l DNA packing inside E. coli bacterial cells, where the environment is crowded due to the presence of proteins, bacterial DNA and salts. In contrast to in vitro packing for a capsid with a long tail, our results indicate that there is a highly variable waiting time before packing initiates. In addition, for a tailless capsid, we find that packing the semiflexible polymer is slower than packing into a capsid with long tail. However, this reverses at large densities of crowding particles: packing into a tailless capsid is faster.
2158-PosStructure and Dynamics of Alzheimer's Associated Amyloid-Beta Peptide
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