In this study, we
outline the synthesis of isatin–ferrocenyl
chalcone and 1H-1,2,3-triazole-tethered isatin–ferrocene
conjugates along with their antimicrobial evaluation against the human
mucosal pathogen Trichomonas vaginalis. The introduction of a triazole ring among the synthesized conjugates
improved the activity profiles with most of the compounds in the library,
exhibiting 100% growth inhibition in a preliminary susceptibility
screen at 100 μM. IC50 determination of the most
potent compounds in the set revealed an inhibitory range between 2
and 13 μM. Normal flora microbiome are unaffected by these compounds,
suggesting that these may be new chemical scaffolds for the discovery
of new drugs against trichomonad infections.
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