Hospital-specific electronic health record systems are used to inform clinical practice about best practices and quality improvements. Many surgical centers have developed deterministic clinical decision rules to discover adverse events (e.g. postoperative complications) using electronic health record data. However, these data provide opportunities to use probabilistic methods for early prediction of adverse health events, which may be more informative than deterministic algorithms. Electronic health record data from a set of 9598 colorectal surgery cases from 2010 to 2014 were used to predict the occurrence of selected complications including surgical site infection, ileus, and bleeding. Consistent with previous studies, we find a high rate of missing values for both covariates and complication information (4-90%). Several machine learning classification methods are trained on an 80% random sample of cases and tested on a remaining holdout set. Predictive performance varies by complication, although an area under the receiver operating characteristic curve as high as 0.86 on testing data was achieved for bleeding complications, and accuracy for all complications compares favorably to existing clinical decision rules. Our results confirm that electronic health records provide opportunities for improved risk prediction of surgical complications; however, consideration of data quality and consistency standards is an important step in predictive modeling with such data.

The pineapple express (PE) phenomenon is responsible for producing extreme winter precipitation events on the west coast of the United States and Canada. We study regional climate models’ ability to reproduce these events by defining a quantity that captures the spatial extent and intensity of PE events. We use bivariate extreme value theory to model the tail dependence of this quantity as seen in observational data and the Weather Research and Forecasting (WRF) regional climate model driven by reanalysis, and we find tail dependence between the two. To link to synoptic‐scale processes, we use daily mean sea‐level pressure fields from the reanalysis product to develop a daily “PE index” for extreme precipitation that exhibits tail dependence with our observational quantity. Other models from the North American Regional Climate Change Assessment Program ensemble are used to estimate the future marginal distributions of reanalysis‐driven WRF output and observational precipitation. Finally, we employ the fitted tail dependence model to simulate observational precipitation measurements in the future, given output from a future run of WRF. We find evidence of a change in the tail behavior of precipitation from current to future climates, and examination of PE index values of simulated events suggests increases in frequency and intensity of PE precipitation in the future scenario. Copyright © 2012 John Wiley & Sons, Ltd.

Accurate specification of a likelihood function is becoming increasingly difficult in many inference problems in astronomy. As sample sizes resulting from astronomical surveys continue to grow, deficiencies in the likelihood function lead to larger biases in key parameter estimates. These deficiencies result from the oversimplification of the physical processes that generated the data, and from the failure to account for observational limitations. Unfortunately, realistic models often do not yield an analytical form for the likelihood. The estimation of a stellar initial mass function (IMF) is an important example. The stellar IMF is the mass distribution of stars initially formed in a given cluster of stars, a population which is not directly observable due to stellar evolution and other disruptions and observational limitations of the cluster. There are several difficulties with specifying a likelihood in this setting since the physical processes and observational challenges result in measurable masses that cannot legitimately be considered independent draws from an IMF. This work improves inference of the IMF by using an approximate Bayesian computation approach that both accounts for observational and astrophysical effects and incorporates a physically-motivated model for star cluster formation. The methodology is illustrated via a simulation study, demonstrating that the proposed approach can recover the true posterior in realistic situations, and applied to observations from astrophysical simulation data.

[1] We introduce novel methodology to examine the ability of six regional climate models (RCMs) in the North American Regional Climate Change Assessment Program (NARCCAP) ensemble to simulate past extreme precipitation events seen in the observational record over two different regions and seasons. Our primary objective is to examine the strength of daily correspondence of extreme precipitation events between observations and the output of both the RCMs and the driving reanalysis product. To explore this correspondence, we employ methods from multivariate extreme value theory. These methods require that we account for marginal behavior, and we first model and compare climatological quantities which describe tail behavior of daily precipitation for both the observations and model output before turning attention to quantifying the correspondence of the extreme events. Daily precipitation in a West Coast region of North America is analyzed in two seasons, and it is found that the simulated extreme events from the reanalysis-driven NARCCAP models exhibit strong daily correspondence to extreme events in the observational record. Precipitation over a central region of the United States is examined, and we find some daily correspondence between winter extremes simulated by reanalysis-driven NARCCAP models and those seen in observations, but no such correspondence is found for summer extremes. Furthermore, we find greater discrepancies among the NARCCAP models in the tail characteristics of the distribution of daily summer precipitation over this region than seen in precipitation over the West Coast region. We find that the models which employ spectral nudging exhibit stronger tail dependence to observations in the central region.

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