Figure 1Clinical course of PLP139-151-induced EAE in SJL lpr/lpr and SJL +/lpr mice. EAE was induced by immunization with 50 µg PLP139-151 in CFA supplemented with 200 µg M. tuberculosis. Mice were monitored and graded for clinical disease as described in Methods. Data represent cumulative results from separate experiments. In a few experiments SJL +/+ mice were also tested and showed a disease course similar to their SJL +/lpr littermates.
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