The sabkha of Abu Dhabi was formed during the past 7,000 years by wind erosion of pre-existing dunes and progradation of subaqueous, intertidal, and supratidal carbonate sediments. Marine transgression began in this area about 7,000 years ago and reached an apparent high about 1 m above its present level somewhat prior to 4,000 years B.P. Since then progradation of intertidal and supratidal sediments has taken place; this began 3,750 years ago. Arid conditions over the sabkha have produced large amounts of gypsum and anhq'drite and lesser amounts of dolomite, magnesite, celestite and halite. G . EVANS ET AL. Fig.2. The sabkha. related to topography and groundwater levels, the error in vertical closure in the survey was limited to a maximum of 5 cm. At strategically located stations, pits were dug, piston barrel cores obtained, and samples recovered from cased holes by means of a wire line bailer (Fig.3). Sedimentology, 12 (1969) 145-159Sedimentology, 12 (1969) 145-159

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We report the design, synthesis, and biological evaluation of some potent small-molecule neuropilin-1 (NRP1) antagonists. NRP1 is implicated in the immune response to tumors, particularly in Treg cell fragility, required for PD1 checkpoint blockade. The design of these compounds was based on a previously identified compound EG00229. The design of these molecules was informed and supported by X-ray crystal structures. Compound 1 (EG01377) was identified as having properties suitable for further investigation. Compound 1 was then tested in several in vitro assays and was shown to have antiangiogenic, antimigratory, and antitumor effects. Remarkably, 1 was shown to be selective for NRP1 over the closely related protein NRP2. In purified Nrp1+, FoxP3+, and CD25+ populations of Tregs from mice, 1 was able to block a glioma-conditioned medium-induced increase in TGFβ production. This comprehensive characterization of a small-molecule NRP1 antagonist provides the basis for future in vivo studies.

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