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EVALUATION OF ANTICONVULSANTSvariety of treatment times, concentrations, etc. The results are summarized in Table I. I n an extension of these observations Volker and Manahan checked the effectiveness of the N-palmitoyl sarcosinate in reducing enamel solubility by measuring the amount of phosphate dissolved by the buffer. Results by this procedure were in good agreement with the gravimetric and calcium titration findings. There was also an indication that foaming must be held to a minimum during the treatment step unless highly purified compound is used. It is also interesting that a 14 hour water rinsing of enamel which had been treated with sodium X-palmitoyl sarcosinate did not result in any appreciable loss of effectiveness.Studies by one of the investigators (R.D. M.) showed that the sodium N-myristoyl, Npalmitoyl and K-stearoyl sarcosinates were more effective in reducing enamel solubility than the K-lauroyl derivative. A 2% reduction in the solubility of enamel in a pH 4.0 acetate buffer was obtained by treating the enamel for one hour with a 0.1% solution of sodium N-lauroyl sarcosinate. Under comparable test conditions the S-myristoyl, Npalmitoyl and K-stearoyl sarcosinates gave reductions in enamel solubility of 11%, 53%, and 15% respectively. Only the 53% reduction exceeded that obtained with sodium fluoride, which was 31% under these conditions.Discussion. Since solutions of sodium Npalmitoyl sarcosinate have been shown to be comparable to solutions of sodium fluoride in reducing enamel solubility and since this compound and the closely related sodium K-lauroyl sarcosinate have been reported to have a prolonged inhibiting effect on acid production in the tooth surface plaque, it is suggested that it be further tested in experimental animals to determine if it is effective in vivo. Thereafter it should be evaluated in a clinical test in human subjects for the inhibition of dental caries.Summary. Of the N-acyl derivatives of sodium sarcosine studied, sodium N-lauroyl sarcosinate produced the least effect and sodium N-palmitoyl sarcosinate produced the greatest effect in reducing the acid solubility of powdered human enamel. Aqueous solutions of 170~ 0.5%, 0.1% and 0.01% of sodium N-palmitoyl sarcosinate have been shown to reduce the solubility of powdered human enamel to a degree comparable to that observed with sodium fluoride solutions. These observations may be of importance in the prevention of dental caries.

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In acupuncture an increase of some substance at the reactive site seems to be required in order to have a biochemical response. Among the substances to be considered are the neurohormones. Experimentally, the sympathetic and parasympathetic neurohormones are shown to be involved in analgesia and in the transmission of nerve impulses.