Objectives: Asymmetry of the renal blood flow is a frequent finding in severe hypertension. Symmetric dimethylarginine (SDMA), the structural isomer of asymmetric dimethylarginine (ADMA), has been shown to be an excellent marker of renal function in human and animal studies, while ADMA is more related to endothelial dysfunction. Given that SDMA is subject to renal metabolism and tends to be higher in subjects with a reduced glomerular filtration rate, we questioned whether increased SDMA levels in hypertensive patients could be related to an asymmetric renal perfusion.
Background: We were to evaluate the relation of left ventricular (LV) geometry and dynamic intraventricular obstruction (IVO) during dobutamine stress echocardiography (DSE) which may be responsible for breathlessness in some elderly patients and in selected patients complaining of effort chest discomfort/dyspnea without coronary heart disease in patients with hypertension.
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