bital buffer of 0.075 ionic strength and pH 8.6. Either 0.01 or 0.02 cc. of spinal fluid concentrate, depending on protein concentration, can be placed on the electrophoresis paper. The grade of paper used was Schleicher and Schuell 2043-A. The electrophoresis proceeded for about 16 hours at a current strength of 2.5 ma. At the end of that time, the papers were dried at a temperature of 120 to 130 C (248 to 266 F), stained according to the Spinco procedure B, washed in methanol, and then stained with brom thymol blue for one-half hour. They were decolorized with three rinses of 5% acetic acid solution and dried. The color of the dye was intensified by exposure to ammonia vapors, and the intensity of dye was measured in the Spinco analytrol apparatus.These pattern changes of protein content in the spinal fluid raise the following questions as to their significance: were these changes representative of toxic effects on the cellular permeability at the blood brain barrier, thus allowing for the albuminglobulin ratio reversal, or was this a poisoning effect to the neurons of the extrapyramidal portion of the brain known as the striopallidal system? The effects caused damage to the cerebral tissues and altered the metabolic processes which allowed for the pattern change. This latter point seems more likely in view of the pathology observed in the brain associated with viral, carbon monoxide, and other toxins that effect the striopallidal system.1 It seemed that this would indicate that phenothiazine drugs had a direct neuronal toxic effect caused in a chemical biotaxic manner to indicate a neural affinity for these specific neurons. Summary A case of triflupromazine hydrochloride (Vesprin) intoxication produced extrapyramidal symptoms which resulted in a curious dissociation of cerebrospinal fluid protein pattern and albuminglobulin ratio shifts. With the removal of the toxins, these changes seemingly were reversed. 516 Sorter St. References 1. Shev, E.: Toxic Effects of "Tranquilizer" Drugs. To be published. 2. Shaw, E. B.; Dermott, R. V.; Lee, R.; and Burbridge, Neuroparalytic complications occur in 1 of every 287 to 1 of every 8,287 persons receiving the Pasteur antirabies vaccine.1 Greenwood 2 found anover-all incident of one reaction to 5,814 treatments on a world-wide basis in a total series of 1,297,758 treated patients. In the same series, there were 56 fatalities, equivalent to 25% mortality in those suffering a neuroparalytic complication. Latimer and co-workers1 reported 40% mortality in 22 cases of neurological complication reported in the literature. A rabies vaccine prepared from virus grown on duck embryo is now available from commercial sources. This preparation will materially reduce the use of vaccine prepared from rabbit central nervous system.3 However, certain persons may not be able to tolerate the avian embryo vaccine, so it seems unlikely that the rabbit central nervous system preparation (Pasteur vaccine) will fall into complete disuse.4 A person with a severe neuroparalytic reaction to the Se...