Although still preliminary, these results indicate that improved tumor dose homogeneity and a staged treatment regimen may improve hearing preservation in acoustic neuroma patients undergoing stereotactic radiosurgery.
Multisession SRS treatment of vestibular schwannomas results in an excellent rate of tumor control. The hearing, trigeminal nerve, and facial nerve function preservation rates reported here are promising.
Patients with parasagittal meningiomas are at greater risk of developing peritumoral symptomatic edema after SRS. Close follow-up after SRS may be particularly important in such patients. These results highlight the need to pursue strategies that could decrease the incidence of postradiosurgical edema in patients with parasagittal meningioma.
Conflict of interest:Mike Coleman is an employee of Valentis Inc. Thomas Quertermous is the inventor of Del-1, which is licensed to Valentis Inc. and for which he receives licensing fees. Nonstandard abbreviations used: endothelial cell (EC); arginineglycine-aspartic acid (RGD); human VEGF165 (hVEGF165); human Del-1 (hDel-1); chorioallantoic membrane (CAM); avian retrovirus expressing human Hox D3 (CK-D3); CK virus without the insert (CK); green fluorescent protein (GFP); human umbilical vein EC (HUVEC); human microvascular EC (HMVEC).
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