Chronic obstructive pulmonary disease (COPD), an increasing global health problem, may be complicated by acute atherothrombotic events. Although systemic inflammation plays the leading role in atherothrombotic processes, platelet activation and increased coagulation together with oxidative stress can significantly exacerbate atherosclerosis in COPD patients. In this study we determined platelet count, mean platelet volume (MPV) and classical markers of systemic inflammation - serum C-reactive protein (CRP), white blood cell (WBC) count and the relative proportion of segmented neutrophils in COPD patients, and compared them to those from the healthy controls. The most important and novel finding of this study was that patients with COPD had a significantly increased platelet count, along with a reduced MPV when compared to healthy controls (286 vs. 260 × 10(9)/l; 9.6 vs. 8.7 fL, respectively). Cigarette smoking had no influence on these results. The presence of systemic inflammation was clearly proved by the increase in classical inflammatory markers (CRP, WBC and segmented neutrophil count).
Hema to loš ki bi lje zi ane mi je i kon cen tra ci ja C-reak tiv nog pro tei na kod sta bil ne kro nič ne op struk cij ske pluć ne bo les ti He ma to lo gi cal mar ke rs of ane mia and C-reac ti ve pro tein in pa tien ts wi th stab le chro nic ob struc ti ve pul mo na ry di sea se Do lo res Pan ci rov 1 , Va nja Radišić Bi ljak 2 , Gor da na Stjepanović 3 , Iva na Če pe lak 41 Od jel za bio ke mij sko-he ma to loš ku di jag nos ti ku, Op ća bol ni ca "Dr. Ivo Pedišić", Si sak 1 De par tme nt of Bioc he mis try and He ma to lo gy Diag nosis, Dr. Ivo Pedišić Ge ne ral Hos pi tal, Si sak, Croatia 2 Me di cin sko-bio ke mij ski labo ra to rij, Po lik li ni ka "Sun ce", Zag reb 2 Me di cal Bioc he mis try La bo ra to ry, Sun ce IHC, In ter na tio nal Heal th Cen ter, Zag reb, Croatia 3 Pul mo loš ki od jel, Op ća bol ni ca "Dr. Ivo Pedišić", Si sak 3 De par tme nt of Pul monolo gy, Dr. Ivo Pedišić Ge ne ral Hos pi tal, Si sak, Croatia 4 Za vod za me di cin sku bio ke mi ju i he ma to lo gi ju Far ma ceut sko-bio ke mij skog fa kul te ta Sveu či liš ta u Zag re bu, Zag reb 4 De par tme nt of Me di cal Bioc he mis try and He ma to lo gy, School of Phar ma cy and Bioc he mis try, Uni ver si ty of Zag reb, Zag reb, Croa tia Sa že takUvod: Cilj is tra ži va nja bio je od re di ti vri jed nos ti he ma to loš kih bi lje ga anemi je i kon cen tra ci je C-reak tiv nog pro tei na (CRP) kod bo les ni ka obo lje lih od sta bil ne kro nič ne op struk cij ske pluć ne bo les ti (KOPB), ka ko bi se ut vr di la prisutno st ane mi je, stu panj sis tem ske upa le i ko re la ci ja iz me đu ana li ta. Ma te ri ja li i me to de: U is pi ti va nje je bi lo uk lju če no 150 boles ni ka s KOPB (for si ra ni ek spi racij ski vo lu men u pr voj se kun di (en gl. for ced expi ra to ry volu me in 1 se co nd (FEV 1 ) = 48 ± 21%) i 51 kon trol ni is pi ta nik (FEV 1 = 106 ± 15%). Pre ma smjer ni ca ma Glo bal ne ini ci ja ti ve za kro ničnu op struk cij sku plućnu bo le st (en gl. Glo bal Ini tia ti ve for Chro nic Ob struc ti ve Lu ng Di sea se, GOLD) bo les ni ci su po di je ljeni u če ti ri pod sku pi ne, a pre ma kri te ri ji ma SZO za ane miju u dvi je sku pi ne: is pi ta ni ci s ane mi jom i bez nje. Kon cen tra ci ja CRP u se ru mu od re đe na je imu no tur bi di met rij skom me to dom, a kon cen tra ci ja he ma to loških bi lje ga pro toč nom ci to met ri jom. Re zul ta ti: Ni je na đe na sta tis tič ki zna čaj na raz li ka u bro ju erit ro ci ta, kon centra ci ji he mog lo bi na i vri jed nos ti ma he ma tok ri ta iz me đu sku pi ne svih bo lesni ka s KOPB i kon trol ne sku pi ne, kao ni iz me đu pod sku pi na GOLD i kon trol ne sku pi ne. Ane mi ja je bi la pri sut na kod 24% bo les ni ka. Kon cen tra ci ja CRP bi la je sta tis tič ki zna čaj no vi ša kod sku pi ne svih bo les ni ka s KOPB (P < 0,001), svih pod sku pi na GOLD (I. P < 0,001; IIA., IIB., III. P < 0,001) i pod sku pi na s ane mijom i bez nje (P < 0,001) u us po red bi s kon trol nom sku pi nom. Spe ci fi č no st i os jet lji vo st CRP od re đe na je ROC anali zom i po ka za...
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