Base stations represent the main contributor to the energy consumption of a mobile cellular network. Since traffic load in mobile networks significantly varies during a working or weekend day, it is important to quantify the influence of these variations on the base station power consumption. Therefore, this paper investigates changes in the instantaneous power consumption of GSM (Global System for Mobile Communications) and UMTS (Universal Mobile Telecommunications System) base stations according to their respective traffic load. The real data in terms of the power consumption and traffic load have been obtained from continuous measurements performed on a fully operated base station site. Measurements show the existence of a direct relationship between base station traffic load and power consumption. According to this relationship, we develop a linear power consumption model for base stations of both technologies. This paper also gives an overview of the most important concepts which are being proposed to make cellular networks more energy-efficient.
The chase for the structure of azaspiracid‐1 has ended with a revised structure (see picture). The total synthesis of this challenging target has closed another chapter in this intriguing chemical detective story and allowed the assignment of the relative and absolute configuration of the molecule.
The molecular structure of azaspiracid-1, a neurotoxin isolated from mussels, has been elucidated by total synthesis which also enriched its supplies. The degradatively derived fragments of this marine biotoxin, compounds 5 (EFGHI), 6 (FGHI), and 40 (ABCD), were matched with synthetic materials, thus confirming their structural identities. Based on this detective work, a new structure of azaspiracid-1 (i.e., 1) was proposed and constructed by total synthesis. The final strategy for the total synthesis of azaspiracid-1 featured a dithiane anion (C(21)-C(27) fragment) reacting with a pentafluorophenol ester (C(1)-C(20) fragment) followed by a Stille-type union of an advanced allylic acetate substrate (C(1)-C(27) fragment) with a vinyl stannane as the main coupling processes to assemble the carbon skeleton of the molecule. In addition to the total synthesis of azaspiracid-1 (1), the syntheses of its C(1)-C(20) epimer (2) and of several truncated analogues for biological investigations are described.
Syntheses of the three key building blocks (65, 98, and 100) required for the total synthesis of the proposed structure of azaspiracid-1 (1a) are described. Key steps include a TMSOTf-induced ring-closing cascade to form the ABC rings of tetracycle 65, a neodymium-catalyzed internal aminal formation for the construction of intermediate 98, and a Nozaki-Hiyama-Kishi coupling to assemble the required carbon chain of fragment 100. The synthesized fragments, obtained stereoselectively in both their enantiomeric forms, were expected to allow for the construction of all four stereoisomers proposed as possible structures of azaspiracid-1 (1a-d), thus allowing the determination of both the relative and absolute stereochemistry of the natural product.
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