The omnipresent character of C−H bonds in organic molecules gives a wide variety of opportunities for the synthesis of a number of functionalized molecules by the activation of the C−H bonds. One of those methods is gold‐catalyzed C−H activation. Recent developments in the area of gold‐catalyzed C−H activation involves annulation reactions leading to the formation of heterocyclic compounds, Au‐catalyzed cross coupling reactions, and C−H functionalization reactions with high atom efficiency. In this short review we summarize the developments and studies carried out in gold‐catalyzed C−H activation over the past decade.
Microwave assisted synthesis of N-heterocycles with short reaction time, high yields and high product purities along with a decrease in the rate of by-product formation.
The first manganese‐catalyzed modified Clauson‐Kaas reaction for N‐substituted pyrrole synthesis using 2,5‐dimethoxytetrahydrofuran with variously substituted aromatic amines has been developed (up to 89% yield). This interesting neat strategy is free from additives including co‐catalysts, ligands, and acids. Relatively low cost, environmentally benign, and handy Mn(NO3)2·4H2O is employed as the catalyst under microwave conditions with a very short reaction time (20 min). The above qualities attest to the green nature of this reaction.
The catalytic activity of silver and its salts in various reactions leads to a vast
variety of organic compounds having significant applications in organic synthesis. This
review gives a comprehensive study on silver-catalyzed multi-component reactions that
attracted the interest of the scientific world through ecofriendly, atom-economic and mild
conditions. The silver-catalyzed multi-component synthesis of organic compounds
including aliphatic, aromatic and heterocycles are divided into subsections based on the
types of bond formed and covers literature up to 2019.
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