1-(2-aminoethyl)-3-methylimidazolium bromide [Aemim]Br ionic liquid were act as a catalyst as well as solvent in the Knoevenagel condensation reaction. The extent of products formed with high yield and more flattering for the synthesis of aliphatic and aromatic esters. The [Aemim]Br can be recycled for 6 runs without great loss of activity. Background: The Knoevenagel condensation was one of the fundamental reactions in organic chemistry both at the laboratory and industrial. Objective: An effective method for the condensation of variety of aliphatic and aromatic carbonyl compounds with ethyl acetoacetate and subsequent hydrolysis, to corresponding α, β -unsaturated esters in [Aemim]Br was achieved. Method: The weighed quantity of [Aemim]Br, an aldehyde and ethyl acetoacetate were carried out at 25OC. The reaction commenced instantaneously making the reaction mixture highly viscous. The product was extracted with ether. The combined organic extracts were dried using anhydrous sodium sulphate, evaporated under reduced pressure and assayed on GC. Results: We could achieve to get Knoevenagel condensation with good yield. Conclusion: An effectual procedure for Knoevenagel condensation of a variety of aliphatic and aromatic aldehydes with active ethyl acetoacetate arise smoothly in the presence of [Aemim]Br without any additional solvents. This is the best method that proved an effective green industrial process.
Aims: A green route for the oxidation of alcohols to corresponding carbonyl compounds in room temperature ionic liquid ([CEMIM]BH4) was developed by using hydrogen peroxide as the oxygen source. In aqueous solution at room temperature, 0.2 mol% of ([CEMIM]BH4) showed excellent catalytic properties for selective oxidation of aromatic and aliphatic alcohols Background: One of the vital reactions in organic synthesis is the oxidation of alcohols to carbonyl compounds. In particular, the conversion of primary alcohols to aldehydes has received a variety of applications as they are used as intermediates in fine chemicals mostly for the perfume industry. Objective: In the present work, we have reported an effective green route for the selective oxidation of alcohols to the carbonyl compounds using peroxide in an ionic liquid 1-carboxyethyl-3-methyl-imidazolium tetrahydroborate ([CEMIM]BH4) Methods:: A mixture of alcohol (2 mmol), ([CEMIM]BH4) (0.2 mol%), H2O2 (2 mmol) were stirred thoroughly with the help of a magnetic stirrer for 10 min at ambient temperature Results: The catalytic activity of ([CEMIM]BH4) is very effective, which reflects its good solvating nature during the oxidation. Conclusion: In conclusion, the series of experiments described represents a useful method for the oxidation of primary and secondary alcohols to carbonyl compounds at room temperature. The catalyst can be easily prepared and is therefore extremely cost-effective. The rapid reaction times for the substrates mean a large number of materials may be screened in parallel over a short period of time.
: Synthesis of chalcone by Claisen–Schmidt condensation using recyclable L- aspartic acid coupled imidazolium-based ionic liquid as a green synthetic approach has been developed. Present work offers significant advantages such as high yield, enhanced reaction speed even at room temperature, catalyst reusability, and the involvement of non-toxic reagents. Background: Chalcones are a flavonoid family and have pharmacological and biological activities. It includes antibacterial, antifungal, immunosuppressive, and anti-nociceptive properties. Objective: Ionic liquid has emerged as a powerful tool for molecular organic solvents and wide liquid range, ease of recovery and reuse, and making them a greener alternative to volatile organic solvents. Thus, our objective was to employ them as dual catalyst and solvent systems to synthesize chalcone via CS condensation in the present work. Method: In a typical experiment, benzaldehyde (10 mmol), acetophenone (10 mmol), and 2.5 mol% (L-AAIL) ionic liquid were mixed in a 50 mL round-bottom flask. The reaction was preceded quickly at room temperature with stirring, the resulting mixture became a biphasic system with the residue at the bottom and the upper phase containing some unreacted substrate separated from the catalyst by filtration and decantation. The catalyst was extracted with CH2Cl2 and split for the next cycle. Results: Claisen–Schmidt condensation accomplished with reasonable to good yields, ranged from 78 to 95% at room temperature in the presence of the [L-AAIL], as compared to the traditional route at more than 100O C. Conclusion: [L-AAIL] are found a highly efficient and eco-friendly catalyst for synthesizing chalcone derivatives at room temperature. [L-AAIL] as a solvent and catalyst will exhibit real advantages by providing a ‘green’ process with the safer operation, Short reaction periods, mild reaction conditions, easier separation, and reusability of ionic liquid made this methodology valuable for synthetic organic chemists as well as industry.
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