We applied a new in silico approach for fishing protease-substrate motifs to design a kallirein 7 (KLK7)-specific phosphonate activity-based probe (ABP) to quantify the active KLK7 in situ. Epidermal application...

Saturn's satellite Enceladus is proposed to have a soda‐type subsurface ocean with temperature able to support life and an iron ore‐based core. Here, it was demonstrated that ocean chemistry related to Enceladus can support the development of Fe‐based hydrothermal vents, one of the places suggested to be the cradle of life. The Fe‐based chemical gardens were characterized with Fourier‐transform (FT)IR spectroscopy and XRD. The developed chemobrionic structures catalyzed the condensation polymerization of simple organic prebiotic molecules to kerogens. Further, they could passively catalyze the condensation of the prebiotic molecule formamide to larger polymers, suggesting that elementary biochemical precursors could have emerged in Enceladus.

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Kallikrein 7 (KLK7) is a chymotrypsin-like serine protease with established roles in skin diseases like the rare Netherton syndrome and common atopic dermatitis. Here, a mixed alkyl aryl phosphonate quenched...