other exogenous ROS activate aerobic metabolism and induce macrophage activation. This includes the previously established non-specifi c stimulation of the endogenous interferon system by ROS-activated macrophages [4], which may have a special place in the clinical effects of Parkon.
For more than 25 years, we have begun an experimental study of the physiological effect of micromolar concentrations of reactive oxygen species on the regulatory functions of the central nervous system. We found that these effects extend to the CNS centers and hormonal regulation of the hypothalamus and pituitary gland [1-4], as well as in the control of BBB permeability [5].
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