Purpose: We asked why endometrial cancer sometimes vanishes. Methods: A total of 454 patients diagnosed with endometrioid-type endometrial cancer (EC) (via endometrial sampling) and treated in our clinic over the past 5 years were enrolled. The patients were divided into two groups: vanishing and residual, depending on whether a tumor was detected in the postoperative hysterectomy specimen. Patient age, numbers of pregnancies and deliveries, menopausal status, systemic disease status, hemogram parameters, International Federation of Gynecology and Obstetrics (FIGO) grade, and invasion status (evident on magnetic resonance imaging [MRI]) were compared between the groups. Results: ECs vanished in 42 (9.25%) patients. The vanishing rates were 19.7% (37/187) in FIGO grade 1 patients, 2.1% (5/238) in grade 2 patients, and 0% (0/29) in grade 3 patients. The average age was lower in the vanishing than the residual group, but the premenopausal status and grade 1 tumor rates were higher (both p < 0.001). An absence of invasion (as revealed by MRI) was more common in the vanishing group (p < 0.001). No recurrence developed in the vanishing group, but recurrences were noted in 3.3% (14/412) of the residual group. There were no significant between-group differences in any of the numbers of pregnancies or births, systemic disease status, or hemogram parameters (all p > 0.05). Conclusion:Vanishing EC is more likely in premenopausal women with endometrioid grade 1 EC (as revealed by endometrial biopsy) who lack myometrial invasion on MRI.
AMAÇ: Bu çalışmanın amacı; BRCA1/2 (breast cancer1/2) gen mutasyonu nedeniyle proflaktik cerrahi (bilateral salpingo-ooforektomi; BSO) yapılan kadınlarda demografik ve tıbbi özelliklerin BRCA1 ve BRCA2 gen mutasyonu taşıyıcıları arasında karşılaştırılmasıdır.GEREÇ VE YÖNTEM: Kliniğimizde son 5 yıl içerisinde BRCA1/2 gen mutasyonu saptanmış ve proflaktik cerrahi (BSO) yapılmış olan 24 kadın çalışmaya alındı. BRCA1 ve BRCA2 gen mutasyonu saptanan hastalar yaş, gebelik ve doğum sayısı, vücut kitle indeksi (VKİ), Ca125 değeri, infertilite ve meme kanseri öyküsü, cerrahi şekli ve postop patoloji sonuçları açısından karşılaştırıldı.BULGULAR: Çalışmaya alınan hastaların yaş ortalaması 45,5±5,8, VKİ 27,6±5,4kg/m2, Ca125 değeri 17,9±14,1İÜ/ml saptanmış olup hastaların %79,2’sinde meme kanseri öyküsü mevcuttu. Hastaların %62,5’inde BRCA1 ve %37,5’inde BRCA2 gen mutasyonu mevcuttu. BRCA1 ve BRCA2 grupları arasında yapılan karşılaştırmada yaş, gebelik ve doğum sayısı, VKİ, Ca125 değeri, infertilite ve meme kanseri öyküsü, cerrahi şekli ve postoperatif patoloji sonuçları açısından her iki grup arasında istatistiksel olarak anlamlı fark saptanmadı (p>0,05). Postoperatif patolojik değerlendirme neticesinde bir hastada over kanseri (BRCA1 grubunda) saptandı.SONUÇ: BRCA1 ve BRCA2 gen mutasyonu olan hastalarda demografik ve tıbbi özellikler açısından fark bulunmayıp, nihai patoloji sonucunda malignite çıkabileceği akılda tutulmalıdır.
Only 2% of all breast cancers are metastatic, making them extremely uncommon. They are frequently mistaken for a primary breast tumor. Although it has been observed, metastatic spread from primary uterine cancers is extremely uncommon. In the literature, our case represents the fourth endometroid adenocarcinoma metastasis from the uterus. Clinical, pathological, and immunohistochemical examination and management of metastatic endometrioid adenocarcinoma of the uterus' extragenital organ were described in this 69‐year‐old patient's case. Immunohistochemical analysis was performed on a breast biopsy taken from the patient who underwent therapy and discovered a breast mass two years later. Metastatic endometrial adenocarcinoma was diagnosed with negative signs pointing to mammaglobin, GCDFP‐15 and GATA3 breasts and markers indicating endometroid adenocarcinomas such as p53, PAX8 and VIMENTIN support. As a result, a thorough clinical history is needed, with special attention to diagnoses of concurrent or prior malignancies, along with clinical examination, appropriate radiological evaluation, and immunohistochemistry. This is necessary to prevent unnecessary surgery, to provide appropriate systemic treatment, to ensure correct diagnosis, and to manage treatment.
Many prognostic factors have been investigated in vulvar cancer patients. In our study, we aimed to compare clinical and pathological prognostic factors and investigate the factors that affect the recurrence and survival in patients with recurrent and non-recurrent squamous cell vulvar cancer. Materials and methods: This retrospective study was conducted in Tepecik Research Hospital, Izmir, Turkey between 1999-2020. The descriptive features, prognostic factors and survival in recurrent patients were evaluated. Results: Tumor invasion depth, surgical margin positivity, lymphovascular space invasion (LVSI), are statistically significant for recurrence (p=0.03, p=0.00, p=0.04). Variables such as age, tumor size, surgical margin distance (mm), tumor localization, presence of metastatic lymph node, operation type (surgery with lymph node dissection) and adjuvant therapy were not found to be statistically significant in terms of recurrent patients with vulvar cancer. There was correlation between recurrence, LVSI, surgical margin positivity, stage and survival in Kaplan Meier survival analysis. Conclusion:As in other studies, many prognostic factors like tumor invasion depth, surgical margin positivity, LVSI are risk factors for recurrence in our study. Stage, LVSI, recurrence, surgical margin positivity were significant factors for survival as well.
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