COVID-19 pandemic has a significant impact on public health, whether directly or indirectly. The first case was seen in Turkey on March 11, and the World Health Organization (WHO) declared a pandemic on March 12, 2020. The study aimed to document the effect of pandemic on dermatology outpatient clinics in Turkey. Fifteen tertiary hospitals from 13 provinces were included in the study, which was conducted between January 12 and May 12, 2020. The International Codes of Diseases (ICD-10) categories and patients' characteristics were evaluated before and after the pandemic. A total of 164 878 patients, 133 131 before and 31 747 after the pandemic, were evaluated. The daily hospital applications were found reduced by 77%. The three of the most frequent diagnoses; dermatitis, acne, and psoriasis remained unchanged after the pandemic. While the frequency of herpes zoster, scabies,

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We recently used our model of experimental neuromyelitis optica spectrum disorder in Lewis rats to show the existence of highly pathogenic aquaporin-4 (AQP4)-specific T cells in Lewis rats. These T cells recognize AQP4 268-285 as their specific antigen, are reactivated behind the blood-brain barrier and deeply infiltrate the central nervous system parenchyma of the optic nerves, the brain and the spinal cord. Thus, these cells differ from T cells with other AQP4 peptide specificities, which are essentially confined to the meninges, as a result of the low local availability of "their" antigen precluding further T cell activation and parenchymal immigration. Although AQP4 268-285-specific T cells are found throughout the entire neuraxis, they have neuromyelitis optica-typical "hotspots" for infiltration ; that is, periventricular and periaqueductal regions, hypothalamus, medulla, the dorsal horns of spinal cord, and the optic nerves. Most remarkably, in the presence of neuromyelitis optica immunoglobulin G, they initiate large astrocyte-destructive lesions that are located predominantly in spinal cord gray matter. We also show that AQP4 268-285-specific T cells can induce retinitis and subsequent damage to retinal axons and neurons, both in the presence and in the absence of neuromyelitis optica immunoglobulin G. Furthermore, within inflammatory lesions induced by AQP4 268-285-specific T cells, retinal astrocytes in the Retinal Nerve Fiber layer (RNFL)/gan-glionic cell layers are spared from the action of neuromyelitis optica immunoglobulin G, whereas M€ uller cells lose AQP4 reactivity. These data show that damage to retinal cells can be a primary event in neuromyelitis optica spectrum disorder. The anterior visual pathway (AVP), which includes the retinas and the pathway from the optic nerves to the lateral geniculate nuclei, is a frequent site of injury, as shown by the presence of optic neuritis during the course of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The optic nerves have several distinguishing structures. First, the long, thin cylindrical dimension of the optic nerves with the cul-de-sac anatomy of the subarachnoid space might cause unique cere-brospinal fluid dynamics, including restricted diffusion of pro-inflammatory elements, retained inflammation, and limited clearance of myelin and axonal debris, followed by enhanced MS and NMOSD lesion formation. In recent study (Hokari et al. Ann Neurol 2016; 79: 605), we showed that the AVP involvement in NMOSD is characterized by the following, compared with MS: (i) longitudinally extensive optic neuritis; (ii) more severe visual impairment and worse prognosis for optic neuritis; (iii) unique aquaporin-4 dynamics; and (iv) more severe neurodegeneration. These data suggest that severe and widespread neuroaxonal damage , and unique dynamics of astrocytes/M€ uller cells with alterations of aquaporin-4 were prominent in the AVP, and might be associated with poor visual function and prognosis in NMOSD. We will discuss progressing ...

Acquired epidermolysis bullosa is a rare subepidermal bullous disease characterized by autoantibodies to type VII collagen, the major component of anchoring fibrils.Although the exact pathophysiologic mechanism remains unclear, reduction or perturbation of the anchoring fibrils results subepidermal blister formation and clinical features such as skin fragility, blisters, erosions, scars, milia and nail loss. Acquired epidermolysis bullosa includes various clinical manifestations resembling genetic epidermolysis bullosa, bullous pemphigoid, cicatricial pemphigoid, Brunsting-Perry pemphigoid and linear immunoglobulin A bullous dermatosis. Numerous treatment options are available but patients are often refractory to treatment. Linear immunoglobulin A bullous dermatosis is another subepidermal bullous disease characterized by the accumulation of IgA antibodies in lamina densa or sublamina densa region of the basement membrane and neutrophil-rich infiltrates in histopathology. It can be seen both in children and adults. The form seen in children usually begins under the age of 5 and it is called chronic bullous disease of childhood. The classical presentation is annular/polycyclic plaques and papules with blistering on perioral and perineal regions, giving a "cluster of jewels" appearance. The adult form is often seen after the fourth decade and clinical features are similar to those of dermatitis herpetiformis, bullous pemphigoid or cicatricial pemphigoid.

Abstract:Geometric expressions and geometric tendencies we see in various places and objects from graffiti to vases whether there is an artistic concern or not entered the art of painting in the West mostly in 20 th century together with 19 th century and had its modern meaning. As a result of the influences caused by the social events experienced, forms and geometric parts were frequently used in abstractions having a boom and language of expression. As the most important event influencing the West in the field of art did not have a similarity in our country which did not include in The Second World War as our art infrastructure, these developments were reflected in a delayed manner. Some attempts starting with transferring what was in the West without changing at first and the artists found their own styles with the effect of the efforts to reflect the objectives new Turkey had established in this period, and they were individuated. In the current study, the transformation and reflections of geometric forms to abstractions in Turkish art of painting in line with the developments in the West was investigated in a periodical order.

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Islak zemine sahip ortak kullanım alanları olan tuvaletler, lavabolar, klozet ve buralarda kullanılan diğer gereçler bakteri üremesi için çok uygun bir ortam oluşturmaktadır ve hastalıklara hatta bazen salgınlara yol açmaktadır. Bu çalışmada üretilecek olan antibakteriyel sırların bu gibi ortamlarda kullanılarak kullanıldığı yerlerde hastalık yapıcı mikroorganizmaların oluşmasına engel olması amaçlanmaktadır. Bu kapsamda, kalsiyum boratlı (CaB2O4) antibakteriyel sırlar hazırlanmış ve antibakteriyel özellikleri incelenmiştir. Antibakteriyel etki için yüksek antibakteriyel aktiviteye sahip olan gümüş (Ag) tercih edilmiş ve sır bileşeninin içerisine molce %0,5 gümüş katılmıştır. Katkısız ve gümüş katkılı Kalsiyum Boratlı sır tozları sol-jel yöntemiyle üretilmiştir. Üretilen tozların XRD analizleri ile bu tozlardan üretilen sırların anti bakteriyel incelemeleri laboratuvar ortamında gerçekleştirilmiştir. Çalışma sonunda %0,5 Ag katkılı kalsiyum borat sırlı seramik karoların E.coli üzerinde antibakteriyel etkiye sahip olduğu tespit edilmiştir.