Background: Biological functions of mammalian Atat1 and its contribution to ␣-tubulin acetylation in vivo remain elusive. Results: Atat1-null mice are viable but possess deficient ␣-tubulin acetylation and a bulge in the dentate gyrus. Conclusion: Mouse Atat1 is a predominant ␣-tubulin acetyltransferase in vivo and fine-tunes hippocampus development. Significance: Mammalian Atat1 is not required for survival and development but may regulate more advanced functions.
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