Subjects and methods Forty three volunteers, 20 girls and 23 boys, with a median age of 131/2 years (range 10 to 16) were investigated. All were healthy and were not taking any drugs (including hormonal contraception). The ranges of body weight and height were 31 to 64 kg (mean 44-5) and 1-47 to 1-67 m (mean 1-57) for girls and 28 to 69 kg (mean 48.2) and 1-43 to 1-83 m (mean 1-61) for boys. The body mass index, calculated by dividing the body weight by the height squared, ranged from 13-1 to 26-0 kg/mi2 (median 18-
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