Common variable immunodeficiency (CVID) is a primary immunodeficiency, which is characterized by insufficiency in the synthesis of immunoglobulins due to the disruption of B cell differentiation. The term "variable" in its name describes the heterogeneous clinical picture (infections, chronic lung disease, autoimmune diseases, gastrointestinal disorders, and malignancy) in this disease. Although the risk of developing malignancy in children with primary immunodeficiency is reported to be 4%, this rate is 10.000 times higher than healthy subjects of similar age. Non-Hodgkin lymphoma (NHL) accounts for 60% of malignancy in primary immunodeficiency patients (1). In the cohorts, the incidence of cancer in CVID patients was 15-21%. The most common malignancy was reported to be NHL, followed by gastric, breast, bladder, and cervix tumors (2-4). Our case shows that Hodgkin lymphoma may rarely develop in CVID and is presented to raise awareness.
Methemoglobinemi; kanda methemoglobin (iki değerli ferröz hemoglobin yerine üç değerli ferrik demir içeren türü) düzeyinin normalden daha yüksek olmasına bağlı gelişen klinik tablodur. Methemoglobinemi konjenital/genetik ve edinsel nedenlere bağlı gelişebilir. Konjenital methemoglobinemiler, yapısal hemoglobin bozuklukları ve methemoglobin redüksiyon enzimlerindeki eksikliklere bağlı olarak gelişir. Edinsel methemoglobinemiler ise oksidan özelliğe sahip ilaç, kimyasal madde ve gıdalara maruziyet yanında süt çocukluğu döneminde görülen bazı hastalıklara bağlı gelişebilir. Prilokain içeren lokal anestezik kullanılarak sünnet yapıldıktan sonra solunum sıkıntısı ve siyanozu başlayan 3.5 aylık erkek bebek hastanemize yatırıldı. Kan methemoglobin düzeyi %31.5 bulundu ve methemoglobinemi tanısı konuldu. İntravenöz askorbik asid ile birlikte oral metilen mavisi uygulanan hastanın 3. saatinde klinik bulgularında düzelme izlendi ve 12. saatinde methemoglobin düzeyi normal olarak bulundu. Methemoglobinemi vakalarında intravenöz askorbik asid ile birlikte oral metilen mavisi de tedavi seçenekleri arasında değerlendirilebilir. Abstract Methemoglobinemia is a disorder characterized by the presence of a higher than normal level of methemoglobin (is a form of hemoglobin that contains ferric
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.