Brittle Nails Syndrome is characterized by fragility of the nail plate, affecting 27%
of women. We evaluated dermatology patients in a cross-sectional study about
perception of nail fragility. One hundred and thirtyeight women were included, with
median age of 36.5 years. Nail examination showed changes in 57% and 49% reported
nail fragility. The first three fingernails were the most affected. Onychoschizia was
related to onychophagia (OR = 3.29), housework (OR = 2.95) and water contact (OR =
2.44). Onychorrhexis had the strongest association with nail fragility perception (OR
= 17.89). The fragility was more perceived by those who were black, of mixed race and
atopic, and was associated with depressed mood.
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