Highlights d B-lymphoid cancer cells can escape to venetoclax by overexpressing MCL-1 d Modulation of AMPK/PKA axis and lymphoid transcription drive venetoclax resistance d Venetoclax resistance involves changes in cellular energy metabolism such as OXPHOS d Metabolic modulators can cooperate with venetoclax to overcome resistance
Graphical AbstractHighlights d Alanine is an essential amino acid for T cells to exit quiescence d Alanine deprivation during early activation leads to functional impairment d T cells do not catabolize alanine during early activation d Extracellular alanine supports protein synthesis
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.