Surpreendeu-nos, trazendo consigo inúmeros impactos na vida das pessoas. Isso tudo causou mudanças não apenas nas questões emocionais e afetivas como, por exemplo, na forma das pessoas se relacionarem, mas também, a respeito da saúde de forma geral, ou seja, psicológica e/ou física. Além do aspecto social e de saúde, a pandemia de COVID-19 provocou também consequências no âmbito político-econômico de diversos países.Com isso, selecionamos trabalhos que abordam o tema, mostrando os impactos em diversas áreas, tais como na epidemiologia, na saúde pública e do trabalhador, nas ciências farmacêuticas, medicina, nutrição, economia e sociedade, odontologia e alguns trabalhos também relacionados à educação em saúde.Em nossos livros selecionamos um dos capítulos para premiação como forma de incentivo para os autores, e entre os excelentes trabalhos selecionados para compor este livro, o premiado foi o capítulo 16, intitulado "Relação do desenvolvimento de delirium em pacientes com COVID-19 hospitalizados em unidade de terapia intensiva".
Only in the year 2018, over two million cases of breast cancer worldwide have been reported, often treated through mastectomy, showing the importance of the study of this procedure, in relation to the physical, psychological and spiritual sequelae of the patients. The objective was to evaluate how these sequels favor the development of post-surgery depression. A bibliometric research was developed in the Portal of Periodicals of the Coordination for the Improvement of Higher Education Personnel, using the following key words ["mastectomized women" and "depression"] 32 articles found. The results were submitted to the "peer-reviewed journals" filter and “Articles in English and Portuguese”, resulting in 10 selected articles that were then merged compiled with information collected from the official WHO and INCA websites to compose this work. Mastectomy aesthetically affects an important component of assertion of womanliness, sexuality and womanhood, post-surgical depression is a common reaction in these patients. Part of these consequences are of a sexual, affective, social and even altered bodily perception. The importance of family, social and professional support in the rehabilitation of these women is also emphasized. The review of these articles allowed us to verify the need to analyze the reconstruction of the breast in mastectomized women as a matter of mental health, and not only as an aesthetic desire for them.
Droserone (2,5-dihyrdoxy-3-methyl-1,4- naphthoquinone) was prepared from naturally occurring naphthoquinone plumbagin. Plumbagin was isolated from roots of Plumbago zeylanica. Plumbagin was first brominated at C-3 which was subsequently substituted with hydroxy group by a nucleophilic substitution to obtain Droserone. The synthesized compounds were characterized by IR, MS, 1H and 13C NMR spectral data. RP-HPLC was used to ascertain the purity of the obtained compound.
A series of alkyl derivatives of plumbagin (2-methyl-5-hydroxy-1,4-naphthoquinone), analogous to Vitamin K, have been synthesized. Plumbagin reacts with carboxylic acid in presence of silver nitrate and ammonium peroxydisulphate to form its alkyl derivatives. The compounds synthesized were characterized by MS, IR, 1 H and 13C-NMR Spectroscopy. The derivatives prepared may find application as antithrombotic agents and may facilitate designing of similar newer analogues.
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