Fifteen female nurses, aged between 21 and 29 years and employed in an intensive care unit, were examined with the aim of evaluating their psychophysical adaptation to one of the most commonly used, rapidly rotating shift systems, the "metropolitan rota" (2-2-2-2), with the length of the shifts modified according to the work load (including night shifts of 10h) and with the start of the morning shift delayed (to 7 a.m.). Subjective evaluations of work load and psycho-physical conditions as well as performance measures (reaction time, search and memory test), blood pressure and heart rate were recorded at the start, middle and end of the work shifts on the last 4 days of the shift cycle, comprising one morning, one afternoon and two consecutive nights. During the shifts, plasma cortisol and urinary excretion rate of 6-sulphatoxymelatonin, adrenaline and noradrenaline were also recorded, as well as oral temperature and activity-sleep logs. The results showed that this rapidly rotating shift system including two consecutive night shifts does not significantly alter the normal circadian rhythms of the body, particularly as concerns performance levels, body temperature and hormone excretion. Moreover, the lengthening of the night shift to 10h can be considered acceptable in terms of work efficiency, provided that work load is reduced and there are sufficient rest pauses available to compensate for tiredness and sleepiness. On the other hand, the shortening of the day shifts to 7h and the delayed start of the morning shift to 7 a.m. appeared convenient in relation to both work load and sleep duration.
female nurses engaged in a resuscitation unit and working on a fast rotating shift schedule comprising two consecutive night shifts were exposed to short periods (4 x 20 min) of bright light (2350 Ix) during their night duty to test a possible positive effect on their tolerance to night work. Two nights with normal lighting (20-380 Ix) and two nights with bright light were compared. The following positive effects of bright light upon psychophysical conditions and performance efficiency were noted: in particular, signs of better physical fitness; less tiredness and sleepiness; a more balanced sleep pattern; and higher performance efficiency (letter cancellation test). This result could not be attributed to shifts of the internal clock although the exact cause remains to be determined. In fact, hormonal excretion and body temperature did not show any effect from bright light. In addition melatonin excretion was not suppressed appreciably by the bright light used.
Background: To report the baseline phase of the SIEROEPID study on SARS-CoV-2 infection seroprevalence among health workers at the University Hospital of Verona, Italy, between spring and fall 2020; to compare performances of several laboratory tests for SARS-CoV-2 antibody detection. Methods: 5299 voluntary health workers were enrolled from 28 April 2020 to 28 July 2020 to assess immunological response to SARS-CoV-2 infection throughout IgM, IgG and IgA serum levels titration by four laboratory tests. Association of antibody titre with several demographic variables, swab tests and performance tests (sensitivity, specificity, and agreement) were statistically analyzed. Results: The overall seroprevalence was 6%, considering either IgG and IgM, and 4.8% considering IgG. Working in COVID-19 Units was not associated with a statistically significant increase in the number of infected workers. Cohen’s kappa of agreement between MaglumiTM and VivaDiagTM was quite good when considering IgG only (Cohen’s kappa = 78.1%, 95% CI 74.0–82.0%), but was lower considering IgM (Cohen’s kappa = 13.3%, 95% CI 7.8–18.7%). Conclusion: The large sample size with high participation (84.7%), the biobank and the longitudinal design were significant achievements, offering a baseline dataset as the benchmark for risk assessment, health surveillance and management of SARS-CoV-2 infection for the hospital workforce, especially considering the ongoing vaccination campaign. Study results support the national regulator guidelines on using swabs for SARS-CoV-2 screening with health workers and using the serological tests to contribute to the epidemiological assessment of the spread of the virus.
To investigate the origin of insulin in amniotic fluid amniocenteses were carried out in pregnancies with live, dead and anencephalic fetuses. Amniotic fluid insulin of pregnant women bearing live fetuses was 9.0 +/- 2.1 microU/ml; in six women with dead foetuses amniotic fluid insulin was not detected. A significant positive correlation was observed between gestational age and the amniotic fluid concentration of insulin. In the amniotic fluid of the four women bearing anencephalic fetuses, the amount of hormone was within normal limits (10.0 +/- 1.4 microU/ml). Intravenous glucose administration (0.33 g/kg body weight) to the mother doses not influence levels of insulin in amniotic fluid, but brought about changes in amniotic fluid glucose concentration. These findings support the conclusion that human amniotic fluid insulin is of fetal rather than maternal origin.
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