Objective-To see whether cardiac morphological and functional abnormalities in uraemic patients are determined by high blood pressure or if they are an expression of a specific cardiomyopathy. Design-Cross sectional study. Setting-City general hospital in Italy. Haemodialysis for chronic renal failure still carries high mortality (10% per year). Cardiovascular events are the main cause of death (50-60% against 15% in control populations).' Accelerated coronary atherosclerosis, which has been claimed to be linked to lipid abnormalities, high blood pressure, diabetes, altered oxygen delivery at cellular level, and to an unknown uraemic factor, seems to be closely related to this excessive mortality.23The natural course of disease in these patients is also characterised by congestive heart failure, possibly as a result of a specific uraemic cardiomyopathy.
database (www.ppmi-info.org/data), corresponding to newly diagnosed PD patients (n¼198) and an age-matched control group (n¼93). Results: We performed 10-fold cross-validation experiments and measured grading values for the substantia nigra (SN) and subthalamic nucleus (STN). The classifier performance was tested by estimating the Area Under the receiver operating characteristic Curve (AUC). Our results showed statistically significant differences in grading values for left SN (p¼0.013) and left STN (p¼0.0002) between patients and controls. When used to classify individual subjects in the cross-validation experiment the performance of the classifier yields an AUC¼0.662 for the left SN, and AUC¼0.733 for the left STN. Conclusions: We have shown that our method could be applied for detecting PD with AUC similar to Alzheimer Disease vs NC detection shown previously (AUC¼0.73 for hippocampal grading in AD, Coupe et al, 2015).
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