B. performed experiments on HBV-infected patients, analysed data, prepared the figures and edited the manuscript; C.B. and F.G. analysed the expression of genes involved in IL-2 sensing on KCs; A.C. and L.N. generated the lentiviral vectors encoding IL-2; G.G.-A. generated recombinant adeno-associated viruses; W.V.B. and D.D.P. generated rLCMV vectors; M.K., R.O. and L.G.G. provided funding, conceptual advice and edited the manuscript; M.I. designed and coordinated the study, provided funding, analysed the data, and wrote the paper.
Highlights d KCs are required for in vivo reinvigoration of intrahepatically primed T cells by IL-2 d KCs respond to IL-2 and cross-present hepatocellular Ags d Single-cell RNA-seq identifies two distinct populations of KCs d KC2s have enriched IL-2 sensing machinery and Ag presentation capacity
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