Methylenetetrahydrofolate reductase ( MTHFR) gene polymorphism (C677T)] is a well-recognized genetic risk factor for venous thrombosis; however, its association with arterial thrombosis is still under debate. Herein, we evaluated the prevalence of MTHFR C677T polymorphism in Georgian patients in comparison with healthy individuals and its association with arterial thrombosis. We enrolled 214 participants: 101 with arterial thrombosis (71.3% males; mean age: 66.3 ± 12.1 years) and 113 controls (67.3% males; mean age: 56.6 ± 11.3 years). Genomic DNA was extracted from dry blood spot on Whatman filter paper. Polymerase chain reaction was performed to determine MTHFR C677T polymorphism. Frequency of C677T allele polymorphism in controls was 21.2%, which corresponded to heterozygous and homozygous stage frequencies of 35.4% and 3.5%, respectively. In patient group, an allelic frequency of 33.2% was found, which corresponded to the presence of 48.5% of heterozygous and 8.9% of homozygous individuals. Comparing the frequency of mutated alleles between the 2 groups, a significantly high frequency of mutated alleles was found in patient group ( P < .05). In conclusion, high frequency of MTHFR C677T polymorphism found in arterial thrombosis patient group suggests that this polymorphism might increase the risk of arterial thrombosis in Georgian patients.

In this study, we attempt to estimate the effects of various transportation policies on the perceived safety of the built environment. We train a convolutional neural network on a dataset of safety perception scores for Google Street View images taken in Boston, MA . We then apply the trained neural network to a large set of Google Street View images of coordinates in Montreal and Toronto to generate their respective safety perception scores. We estimate probit, logit, and ordinary least squares regression models using our cross-sectional dataset consisting of safety perception scores, as well as transportation policy variables and a set of control variables, by regressing the safety perception scores on the remaining set of variables. We answer our research question by observing the direction, magnitude, and statistical significance of the coefficient estimates associated with the policy variables across all regression models. We studied and cataloged transportation policies planned for over the past 10 years in both cities. We found that those census tracts with the poorest safety scores were the same places where planners focused their transportation investments. The study makes an important contribution to transportation planning methodologies by drawing on the novel data source of Google Street View images, to understand the safety of an area.

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Takotsubo syndrome (TS) is a transient, reversible dysfunction of the left ventricle (LV) without damage to the coronary arteries, which clinically manifests as acute coronary syndrome (ACS) and/or heart failure (HF). We are reporting the clinical case of a 58-year-old Caucasian woman who was admitted to our hospital with a clinical presentation of ACS and HF, but finally was diagnosed with TS. As it is known to us, this is the first case report of TS from Georgia. Accordingly, our goal is to promote scientific interest in this pathology because, till now, there are no modern guidelines or recommendations on the treatment and management of this disease

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