Objective: The aim was to investigate the effects of two different GH dosage regimens on growth, bone geometry and bone strength. Subjects and methods: Final height; parentally adjusted final height; the metacarpal index (MI) SDS, the inner and outer diameters; and the total cross-sectional area (CSA), cortical CSA, medullary CSA and bone strength (Bending Breaking Resistance Index (BBRI)) were evaluated at the metacarpal site in two cohorts of GH-deficient children, treated with two different doses of GH. Group 1 (38 patients) was treated with 0.16 mg/kg body weight per week of GH and group 2 (37 patients) with 0.3 mg/kg per week. Results: At the end of treatment, with group 1 vs group 2, height SDS was 20.84^1.07 vs 2 0.46^0.76, and parentally adjusted height SDS was 0.14^1.08 vs 0.27^0.82. Parentally adjusted relative height gain was 1.14^0.89 vs 2.14^0.72 SDS (P , 0.0001). MI SDS was 0.58^1.31 vs 2 0.42^1.54 (P , 0.005). MI SDS gain was 0.07^1.41 vs 20.35^1.85. There was no difference between groups in the outer and inner diameter, in the total and cortical CSAs, whereas medullary CSA was higher in group 2 (P , 0.05). BBRI was 10.02^5.37 vs 11.52^5.49 cm 3 , and BBRI gain was 3.33^5.06 vs 6.88^6.65 (P ¼ 0.01). P values were assessed using student's t-test. Conclusion: Higher GH doses result in a greater height gain and improved bone strength.European Journal of Endocrinology 154 479-482
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