Mechanical barriers prevent the invasion of the surrounding soft tissues within the bone defects. This concept is known as Guided Bone Regeneration (GBR). The knowledge about the local tissue reaction and the time of degradation of absorbable membranes favors the correct clinical indication. This study aimed to evaluate the biocompatibility and biodegradation of a bovine collagen membrane (Lyostypt®, São Gonçalo, Brazil) and compare it to a porcine collagen membrane (Bio-Gide®) implanted in the subcutaneous tissue of mice, following ISO 10993-6:2016. Thirty Balb-C mice were randomly divided into three experimental groups, LT (Lyostypt®), BG (Bio-Gide®), and Sham (without implantation), and subdivided according to the experimental periods (7, 21, and 63 days). The BG was considered non-irritant at seven days and slight and moderate irritant at 21 and 63 days, respectively. The LT presented a small irritant reaction at seven days, a mild reaction after 21, and a reduction in the inflammatory response at 63 days. The biodegradation of the LT occurred more rapidly compared to the BG after 63 days. This study concluded that both membranes were considered biocompatible since their tissue reactions were compatible with the physiological inflammatory process; however, the Bio-Gide® was less degraded during the experimental periods, favoring the guided bone regeneration process.
Twenty-four teeth were extracted en bloc with the marginal periodontal structures and processed for histologic purposes. Measurements were taken from the top of the gingival margin to the apical limit of the junctional epithelium (GM-JE), from the apical limit of the junctional epithelium to the top of the alveolar bone crest (JE-AB), and from the top of the gingival margin to the top of the alveolar bone crest (GM-AB). Data were histometrically analyzed. This first clinical human study demonstrated mean measurements of 1.58 ± 0.41 mm for GM-JE, 1.18 ± 0.42 mm for JE-AB, and 2.75 ± 0.59 mm for GM-AB.
A utilização de implante imediato em regiões posteriores tem apresentado resultados contraditórios. Objetivo: O objetivo deste estudo foi comparar o índice de sucesso e previsibilidade à curto prazo de implantes imediatos instalados em regiões anterior e posterior. Métodos: Um total de 1000 prontuários foram analisados, dos quais 43 foram incluídos neste estudo: Anterior (n=20) e posterior (n=23). Os critérios de inclusão foram: Indicação de extração dentária, instalação de implantes imediatos unitários, no mínimo doze meses de segmento com implante funcional. Os critérios de sucesso foram baseados na escala de saúde dos implantes dentários do Congresso Internacional de Implantologia Oral, eixo I. e II.: ausência de dor, ausência de mobilidade, ausência de exudato e perda óssea de até 4 mm. Valor de p<0.05 foi considerado estatisticamente significante. Resultados: O índice de sucesso dos implantes imediatos foi de 97,7% para implantes em função por pelo menos 12 meses. O uso de biomaterial (p=0,03) e prótese provisória (p<0,0001) foi significantemente maior em região anterior. Não foi encontrado diferença significante quanto a falha dos implantes comparando os dois grupos (p=0,47). Não houve diferença estatisticamente significante entre os grupos, considerando a idade, gênero, motivo da extração, torque inicial, tempo de tratamento e tipo de plataforma do implante (p>0,05). Conclusão: Pode-se concluir que as regiões anterior e posterior apresentaram alta taxa de sucesso a curto prazo quanto a técnica de implante imediato.
This study aimed to analyze Fibroblast Growth Factor-2 (FGF-2) levels in the peri-implant crevicular fluid throughout supportive mucositis therapy. Twenty-six participants with Branemark protocol prosthesis were divided into two groups: the control group, characterized by healthy peri-implants, and the mucositis group, presenting a diagnosis of peri-implant mucositis. All participants underwent clinical examination, radiographic analysis, prosthesis removal, and non-invasive peri-implant therapy (mechanical debridement associated with chlorhexidine 0.12%) during a period of 36 days divided into three intervals. Peri-implant crevicular fluid samples were collected at each interval in order to analyze FGF-2 levels by immuno-enzymatic assay. The control and mucositis groups showed difference in keratinized mucosa. The smaller the range of keratinized mucosa the higher susceptibility of peri-implant mucositis. Throughout the treatment intervals, participants were diagnosed in different groups indicating whether or not the non-invasive therapy was able to treat peri-implant mucositis. There was a significant difference of FGF-2 levels between groups, with the higher FGF-2 levels in the control group (p=0.01). After supportive therapy, the mucositis group showed significantly increased FGF-2 levels (p<0.01) compared to initial levels. After 36 days of supportive therapy, there was a reduction of peri-implant mucositis from 70% to 23%. Clinical and laboratory outcomes showed a clear correlation since FGF-2 levels increased after 36 days. It was concluded that the therapy protocol was effective and promoted a regenerative reaction and FGF-2 can be considered a future target for peri-implant mucositis understanding.
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