There are insufficient data currently available to derive an evidence-based algorithm of the diagnostic pathway for haematuria. A hypothetical algorithm based on the opinion and practice of clinical experts in the review team, other published algorithms and the results of economic modelling is presented in this report. This algorithm is presented, for comparative purposes, alongside current US and UK guidelines. The ideas contained in these algorithms and the specific questions outlined should form the basis of future research. Quality assessment of the diagnostic accuracy studies included in this review highlighted several areas of deficiency.

In checkpoint-inhibitor trials, ORR correlated poorly with OS. For future phase 2 studies, 6-month PFS rate is recommended as an end point.

No abstract

Objectives : To assess the performance of published search filters in finding diagnostic test accuracy studies. Methods : Diagnostic test accuracy search filters were identified by searching medline , our own files and by requesting unpublished filters from colleagues. We applied the filters to a case study review of diagnostic test accuracy studies for urinary tract infections (UTI) in young children. The included studies with records in medline formed the gold standard. The performance of the filters in finding those gold standard records was assessed. Results : We identified twenty-three diagnostic test accuracy search filters for use with medline . The case study systematic review of UTI included 179 studies of diagnostic test accuracy, of which 160 were available in medline . The filters showed a wide range of sensitivities (range: 20.6% to 86.9%) and precision (range: 1% to 9.4%). Conclusions : Our results broadly support those reported in two other studies. The search filters tested do not offer an adequate trade-off between sensitivity and precision to be used to identify studies for systematic reviews. However, there are methods available to explore whether search filters are viable based on an objective statistical analysis of the text and indexing used in records.

No abstract

Analysis 1.10. Comparison 1 NLU vs general inpatient care, Outcome 10 Change in functional Status (admission to discharge)..... Analysis 1.11. Comparison 1 NLU vs general inpatient care, Outcome 11 Length of stay to first discharge from hospital setting..... Analysis 1.12. Comparison 1 NLU vs general inpatient care, Outcome 12 Length of stay to first discharge home.

Many stroke survivors, despite improvements in mortality and morbidity, remain dependent on others for everyday activities. People with stroke need access to effective specialist multidisciplinary rehabilitation services that are organised and integrated within the whole system of health and social care. They also commonly come under the care of generalists in various clinical contexts, including intercurrent illness. This Clinical Medicine Concise Guideline abstracts key recommendations from the National Institute for Health and Care Excellence Clinical Guideline 162 on stroke rehabilitation of particular relevance to clinicians in general medicine, to inform their front-line practice and promote liaison and collaboration with the specialist service.

The current evidence base does not support any general conclusion that self-care support interventions are cost-effective, but ongoing trials may provide clearer evidence.