Eight 15N-labeled nonessential amino acids plus 15NH4Cl were administered over a 10-h period to four healthy adult males using a primed-constant dosage regimen. The amount of 15N excreted in the urine and the urinary ammonia, hippuric acid and plasma alanine 15N enrichments were measured. There was a high degree of consistency across subjects in the ordering of the nine compounds based on the fraction of 15N excreted (Kendall coefficient of concordance W = 0.83, P less than 0.01). Protein synthesis rates were calculated from the urinary ammonia plateau enrichment and the cumulative excretion of 15N. Glycine was one of the few amino acids that gave similar values by both methods.
Transcatheter aortic valve implantation (TAVI) is a relatively new medical intervention. Research on dedicated TAVI devices is an exciting and dynamic field to be explored by professionals involved in technological innovation. The authors describe in this article the first engineering concept and part of the US Patent of a new valve prosthesis. Divided into two pieces to be separately implanted using a single catheter by means of an innovative technique, this device aims at reducing prosthesis and delivery catheter profile. Miniaturization of the valve and delivery system is probably the best solution to reduce the morbidity and mortality that derive from vascular complications associated with TAVI.
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