Breast density does not impact overall CAD detection of breast cancer. There is no statistically significant difference in breast cancer detection in dense and nondense breasts. However, the detection of breast cancer manifesting as masses is impacted by breast density. The false-positive rate is lower in nondense versus dense breasts. CAD may be particularly advantageous in patients with dense breasts, in which mammography is most challenging.

High-resolution breast-specific scintimammography can depict small (<1-cm), mammographically occult, nonpalpable lesions in women at increased risk for breast cancer not otherwise identified at mammography or physical examination.

The CAD system correctly marked most biopsy-proven breast cancers, with a greater sensitivity for microcalcification than for mass lesions but with no significant difference in performance based on cancer size. CAD was highly effective in detecting even the smallest lesions, with a sensitivity of 92% for lesions of 5 mm or less. CAD is a useful tool for the detection of breast cancer.

No abstract