Paracetamol (acetaminophen) is a ubiquitous drug usually prescribed for its analgesic and antipyretic effects. It is a readily available over-the-counter medication. Consumption of jamu and paracetamol causes pharmacokinetic interaction. This study aimed to determine how much the potential of jamu "pegal linu" affected pharmacokinetics profile of paracetamol. Paracetamol levels in rat plasma were analyzed by spectrophotometry UV-Vis using regression and residual methods to primary pharmacokinetic profile: constant absorption rate (Ka), distribution volume (Vd), maximum plasma concentration (Cpmax), Area Under Curve (AUC), and secondary parameter: constant elimination rate (Ke), half-life elimination (t 1/2 ), maximum concentration (Tmax). Animal subjects were grouped into two categories, group I or paracetamol group (positive control) and group II (paracetamol + jamu "pegal linu") with three Wistar male rats for each group. The result showed that if jamu "pegal linu" was given, the constant absorption rate (Ka) and elimination rate constant (Ke) were lower, but maximum plasma concentration (Cpmax) and Clearance (Cl) remained steady. Others pharmacokinetics, such as maximum concentration (Tmax), half-life elimination (t 1/2 ), distribution volume (Vd), and Area Under Curve (AUC), were higher. The bivariate analysis showed no major different (p > 0,05) for both groups. Jamu "pegal linu" co-administration has a potential effect to allegedly the plasma level of paracetamol.
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