Rhodanine and its derivatives are not only valued for their interesting chemical properties but also present a wide range of bioactivities and their chemical and pharmacological applications have been investigated. From 3-methyl-4-thiorhodanine we synthesized S-acylated and C-acylated products using (some) carboxylic acid chlorides and the obtained products were studied the anti-proliferative activity by a SRB (sulforhodamine B) assay against a human breast cancer cell line. The results showed that C-acylated products are better inhibitors than S-acylated products.
Six 5-arylidene-3-methylrhodanine derivatives were synthesized by the crossed aldolization of aromatic aldehydes with 3- methylrhodanine using 1-butyl-3- methylimidazolium chloride ([BMI]Cl) as phase transfer catalyst in water. The reactions, under microwave irradiation (160 watts) during 10 minutes, afforded the yield of 59–83 %. This is the first time [BMI]Cl was used as phase transfer catalyst in the aldol condensation.
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