A recent study on the immunotherapy treatment of renal cell carcinoma reveals better outcomes in obese patients compared to lean subjects. This enigmatic contradiction has been explained, in the context of the debated obesity paradox, as the effect produced by the cell-cell interaction network on the tumor microenvironment during the immune response. To better understand this hypothesis, we provide a computational framework for the in silico study of the tumor behavior. The starting model of the tumor, based on the cell-cell interaction network, has been described as a multiagent system, whose simulation generates the hypothesized effects on the tumor microenvironment. The medical needs in the immunotherapy design meet the capabilities of a multiagent simulator to reproduce the dynamics of the cell-cell interaction network, meaning a reaction to environmental changes introduced through the experimental data.
In this work a general framework is proposed to support the development of software systems that are able to adapt their behaviour according to the operating environment changes. The proposed approach, named REPTILE, works in a complete proactive manner and relies on Deep Reinforcement Learning-based agents to react to events, referred as novelties, that can affect the expected behaviour of the system. In our framework, two types of novelties are taken into account: those related to the context/environment and those related to the physical architecture itself. The framework, predicting those novelties before their occurrence, extracts time-changing models of the environment and uses a suitable Markov Decision Process to deal with the real-time setting. Moreover, the architecture of our RL agent evolves based on the possible actions that can be taken.
The scarcity of Smart Home data is still a pretty big problem, and in a world where the size of a dataset can often make the difference between a poor performance and a good performance for problems related to machine learning projects, this needs to be resolved. But whereas the problem of retrieving real data cant really be resolved, as most of the time the process of installing sensors and retrieving data can be found to be really expensive and time-consuming, we need to find a faster and easier solution, which is where synthetic data comes in. Here we propose BinarySDG (Binary Synthetic Data Generator) as a flexible and easy way to generate synthetic data for binary sensors.
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