Background
NSAID-exacerbated respiratory disease (N-ERD) is a highly heterogeneous
disorder with various clinical symptoms. The aspirin challenge test is a
gold standard method for its diagnosis, and there are still no reliable in
vitro diagnostic biomarkers yet. Oral challenge tests are time-consuming and
may be associated with a risk of severe systemic reactions. This study aimed
to evaluate whether patients with poor responses to medical management are
more susceptible to being aspirin-sensitive.
Methods
In this cohort study, after CT scanning of all patients and subject
selection, conventional medical treatment was started as follows and
continued for three consecutive months: at first, saline nose wash twice per
day, intranasal beclomethasone spray one puff in each nostril twice per day,
montelukast 10 mg tablet once daily, a ten-day course of oral prednisolone
starting with the dose of 25 mg per day and taper and discontinued
thereafter. Sinonasal outcome test 22 (SNOT22) was used for the evaluation
of symptom severity. Statistical analyses were performed with SPSS version
23, and data were analyzed using an independent samples T-test, paired
T-test, and Receiver operating curve analysis
Results
25 males and 53 females were enrolled in this study, with an average age of
41.56 ± 11.74 years old (18-36). Aspirin challenge test results were
positive in 29 (37.2%) patients. The average SNOT22 scores before the
treatment were 52.97 ± 17.73 and 47.04 ± 18.30 in aspirin-sensitive and
aspirin-tolerant patients, respectively, and decreased to 27.41 ± 16.61 and
24.88 ± 16.72 in aspirin-sensitive and aspirin-tolerant patients after the
treatment, respectively. There was no significant difference in SNOT22
scores between the groups.
Conclusion
The severity of symptoms before treatment and clinical improvement after
treatment are not good predictors of N-ERD.
Background: Asthma as a chronic disease may affect the growth process. The aim of this study was to investigate the anthropometric indices in 2-18 years old children with asthma and compare them with the control group.
Patients and Methods: In a case-control study, 150 asthmatic children with age of 2-18 years as case group and 300 age- and sex-matched healthy children as control group were randomly included. The height, weight, and body mass index (BMI) of both group measured by the standard method and Z score was calculated. Data were analyzed using SPSS, chi-square and analysis of variance.
Results: Totally, 290 boys (64.4%) and 160 girls (35.6%) with mean age of 6.58±2.82 years were evaluated. Case group had significantly lower height compared to the healthy control group (117.00±0.17 cm vs. 121.00±0.15 cm respectively, P=0.025). No significant differences were detected in weight (23.13±9.75 kg vs. 24.62±10.36 kg, P=0.145) and BMI (16.32±3.10 kg/m2 vs. 16.28±3.16 kg/m2, P=0.900) between case and control groups, respectively. There were no significant relationships between normal and abnormal Z scores of height, weight and BMI in case and control group (P>0.05).
Conclusion: Despite 4 cm difference between the age of two groups, no differences in height, weight ad BMI between two groups may be due to good control of the disease in the case group or lack of significant growth related effect of asthma.
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