Sections of tissue from 256 patients on which a histological diagnosis of hydatidiform mole had been made were reviewed by a visiting pathologist. There was agreement between the reporting pathologists and the visiting pathologist in only 55.1 per cent of cases, a less severe diagnosis was made by the visiting pathologist in 42-2 per cent of cases. The disagreement was as high as 66.6 per cent with pathologists who rarely worked in the gynaecological field. This study casts serious doubt on the consistency of the histological diagnosis of hydatidiform mole made in any one laboratory and between different laboratories. It is suggested that in epidemiological studies the diagnosis should be made by a panel of pathologists using strict histological criteria and in an individual laboratory diagnosis should be made or confirmed by a pathologist experienced in gynaecological pathology.
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SummaryCases of maternal death on which autopsies were carried out during 1963-9 at Saadi Hospital of Pahlavi University have been reviewed. All deaths, regardless of the cause, in pregnant women at any period of gestation or within 90 days of termination of pregnancy were included in the study. The autopsy rate was 90 per cent. Seventy-three per cent of the patients were from the surrounding district and 27 per cent from the urban area. None of the mothers had antenatal care. The cause of deaths was classified as direct obstetric in 46 per cent of cases, as indirect obstetric in 36 per cent and unrelated in 18 per cent. In all three groups, infection was the leading cause of death.
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