Back ground: Migraine is a common chronic episodic disabling primary headache disorder with associated Symptoms. The neuroendocrinological alterations, disorders of the hypothalamic-hypophysial axis are believed to be implicated in the pathogenesis of primary headache syndromes Objective: The aim is to determine the effect of sex hormones on migraine. Patients and methods: Twenty seven adult patients with migraine and 20 controls were assessed for prolactin,testeron,,LH,FSH were tested with immunofluorometric assay. Results: This study found that migraine is associated with elevated level of FSH, prolactin and testerone P= (<0.05), (<0.05) and (<0.05) respectively .however there was no significant association between LH levels and migraine P (>0,05). Conclusion: There is a significant correlation between levels of hormones and migraine.
OBJECTIVE: Determine the ‎diagnostic validity of serum aspartic acid as a predictor of epilepsy. STUDY DESIGN & METHODOLOGY: This study enrolled 80 epileptic patients and 80 healthy people, and we measure serum level of ‎aspartic acid by using high liquid performance chromatography. RESULTS: Mean serum aspartic acid ‎was significantly higher in patients (26.2 ± 10.1) mg\dl while in control was (2.8 ± 1.36) mg\dl, ‎the result showed that aspartic acid is an excellent predictor area under the curve [AUC] (95%CI) = ‎‎0.988 (0.97 – 1.0) with 96.3% sensitivity and 97.5% specificity for epileptic patients. Also, the ‎result shows generalized seizure has significantly higher mean serum aspartic acid compared to ‎partial type and GTC show significantly higher mean serum aspartic acid compared to ‎myoclonus. CONCLUSION: Aspartic acid serum level markedly elevated in epileptic patients ‎groups in comparison to the healthy group, also shows a marked difference between generalized ‎and partial epilepsy and show different levels between subtypes of epilepsy.‎
Back ground: Migraine is a common chronic episodic disabling primary headache disorder with associated Symptoms. The neuroendocrinological alterations, disorders of the hypothalamic-hypophysial axis are believed to be implicated in the pathogenesis of primary headache syndromesObjective: The aim is to determine the effect of sex hormones on migraine.Patients and methods: Twenty seven adult patients with migraine and 20 controls were assessed for prolactin,testeron,,LH,FSH were tested with immunofluorometric assay.Results: This study found that migraine is associated with elevated level of FSH, prolactin and testerone P= (<0.05), (<0.05) and (<0.05) respectively .however there was no significant association between LH levels and migraine P (>0,05).Conclusion: There is a significant correlation between levels of hormones and migraine.
Objectives: The aim of this study was to assess the possible the association between +3061 (G>A, rs1143676) missense mutation in exon 24 of the integrin α-4 subunit (ITGA-4) gene and the response to natalizumab in a sample of Iraqi multiple sclerosis patients. Methods: A sample of 59 patients with multiple sclerosis (16 males and 43 females; mean age of 32 years; age range of 15 to 52 years) receiving natalizumab for at least 12 consecutive months were involved in the study between March and August/ 2022. The sample was categorized into two groups according to their response to natalizumab treatment (responders and non-responders). Polymerase chain reaction and Sanger’s sequencing for the extracted deoxyribonucleic acid was performed to identify the polymorphism at ITGA-4 gene promoter region. Results: The 3061 AA and AG genotypes were present in both groups (responders and non-responders to natalizumab treatment) with the lack of the wild form GG genotype. The AG genotype was significantly present in the non-responders’ group and appeared to have a significant impact on the responsiveness to natalizumab by increasing the propensity of being non-responder with a positive correlation (Phi-coefficient of 0.294) on the contrary of AA genotype. Conclusion: The +3061 (G.A) missense mutation is related to the response to natalizumab in multiple sclerosis patients with the AG genotype, thereby increasing the likelihood of non-response significantly.
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