Background: Biotemplates are attractive templates for the synthesis of nanometals and inorganic compound nanostructures. Methods: In this work, for the first time, iron oxide quantum dot nanoparticles (QDNPs) were prepared using albumen as a biotemplate. Next, the prepared nanoparticles were characterized using dynamic light scattering for determination and evaluation of the hydrodynamic diameter and zeta potential of the particles. Moreover, optical and scanning electron microscopes were applied to evaluate morphology. Spherically shaped iron oxide QDNPs were obtained with appropriate particle size and distribution. Fe(NO 3 ) 3 .9H 2 O and egg whites were used as the source of the Fe element and particle size control agent in the aqueous medium, respectively. Afterward, the effect of calcination temperature parameters on the crystallinity purity and size of Fe nanocrystals were investigated. Also, products were characterized by various detection analyses such as thermogravimetry analysis/DTA, XRD, UV-vis, Fourier transform infrared (FT-IR,) transmission electron microscopy, and SEM. In order to investigate the antibacterial effect of the synthesized Fe nanobiological samples against bacterial strains, they were dissolved in dimethyl sulfoxide and diluted using distilled water. Then, different serial dilutions of 64 μg/mL, 32 μg/mL, 16 μg/mL, 8 μg/mL, 4 3BCg/mL, 2 μg/mL, 1 μg/mL, and 0.5 μg/mL of nanobiological samples were prepared and added to the Mueller–Hinton agar medium. Results: The minimum inhibitory concentration of the synthesized iron oxide quantum dot nanobiological was determined against pathogenic microbial strains of bacteria including Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens, Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis , and Klebsiella pneumonia on the culture medium plate. Conclusion: The present nanobiological samples can be considered as a new material candidate for antibacterial drugs.
BackgroundFluoroquinolones (FQs) are compounds of major interest with broad antimicrobial activities against community and hospital-acquired infections such as respiratory tract infections (nosocomial pneumonia, chronic bronchitis and tuberculosis), skin and soft tissue infections, bone and joint infections, intra-abdominal infections and sexually transmitted diseases. This broad range of activities along with favorable pharmacokinetic and low toxicity introduced this class of compounds as important antimicrobial chemotherapy agents. The rapid increase in prevalence of FQs resistant microbes in environment motivated medicinal chemists to discover new quinolone-based compounds with potent activities against Gram-positive bacteria.MethodsThe designed compounds were prepared through the two-component reaction between aromatic α-haloketones or α-halooximes and sarafloxacin in the presence of NaHCO3 in DMF, affording the corresponding N-[2-(aryl-3-yl) ethyl] piperazinyl quinolone derivatives in good yields. All synthesized compounds were evaluated for antibacterial activities against Gram-positive [Staphylococcus aureus ATCC 6538p, Micrococcus luteus, ATCC 1110, Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633] and Gram-negative [Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 10031 Pseudomonas aeruginosa ATCC 9027 and Serratia marcescens PTCC 1111] bacteria.ResultsThe antibacterial activities of 24 new compounds were reported as MIC values in comparison to sarafloxacin. The most active compound, 4 g, exhibited similar inhibitory activity against Gram-positive bacteria including S. aureus, S. epidermidis and B. subtilis compared to positive control. Furthermore, benzyloxime incorporated derivatives (4 s-4x) showed poor activity against all tested strains, except 4x.ConclusionThe obtained results indicated that the synthesized compounds containing substituted piperazine moiety at the C-7 position displayed same or weak inhibitory activities compared to sarafloxacin. Graphical abstractᅟ
Introduction: Given the increasing rate of antibiotic resistance among bacterial strains, many researchers have been working to produce new and efficient and inexpensive antibacterial agents. It has been reported that some nanoparticles may be used as novel antimicrobial agents.Here, we evaluated antibacterial properties of nickel oxide (NiO) nanoparticles. Methods: NiO nanoparticles were synthesized using microwave method. In order to control the quality and morphology of nanoparticles, XRD (X-ray diffraction) and SEM (scanning electronmicroscope) were utilized. The antibacterial properties of the nanoparticles were assessed against eight common bacterial strains using agar well diffusion assay. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were measured. Antibiotic resistance pattern of the bacteria to nine antibiotics was obtained by Kirby-Bauer disk diffusion method. Results: The crystalline size and diameter (Dc) of NiO nanoparticles were obtained 40-60 nm. The nanoparticles were found to inhibit the growth of both gram-positive and gram-negative bacteria with higher activity against gram-positive organisms. Among bacterial strains, maximum sensitivity was observed in Staphylococcus epidermidis with MIC and MBC of 0.39 and 0.78 mg/mL, respectively. The bacteria had high resistance to cefazolin, erythromycin, rifampicin,ampicillin, penicillin and streptomycin.Conclusion: NiO nanoparticles exhibited remarkable antibacterial properties against gram positive and gram-negative bacteria and can be a new treatment for human pathogenic and antibiotic-resistant bacteria.
Purpose: In this study, for the first time, new nanoparticles of La 3+ /α-Al 2 O 3 were synthesized with the ultrasonic-assisted hydrothermal method in the presence of honey as an ecofriendly and natural reagent. Methods: The as-synthesized La 3+ /α-Al 2 O 3 nanoparticles were characterized using scanning electron microscopy (SEM), transition electron microscopy (TEM), X-ray diffraction spectroscopy (XRD), energy dispersive X-ray (EDX), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. In this work, we report optimum conditions to synthesize La 3+ /α-Al 2 O 3 nanoparticles as novel material and as a candidate for antibacterial activity in antibacterial drugs. Results and Conclusion: The XRD and SEM micrograph results demonstrate the formation of pure La 3+ /α-Al 2 O 3 nanoparticles with a particle size in the range of 30-80 nm. The synthesis parameters were systematically examined using analysis of variance (ANOVA) through 2k −1 factorial design, and the factors were an assay for product optimization. Various factors such as hydrothermal time, temperature, ultrasound irradiation and interaction between these factors were investigated on the product size of the products. To investigate antibacterial activity of the La 3+ /α-Al 2 O 3 nanoparticles with the minimum inhibitory concentration (MIC) method, different dilutions of nanoparticles as 64,32,16,8,4, 2, 1 and 0.5 μg/mL were dissolved in dimethyl sulfoxide and diluted using distilled water and added to the Mueller-Hinton agar medium containing Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Serratia marcescens as gram-negative bacteria and Bacillus subtilis, Staphylococcus aureus, S. epidermidis and Micrococcus luteus as gram-positive bacteria.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.