Psoriasis is a chronic inflammatory skin disease characterized by recurrent events. Its prevalence around the world is approximately 1-3%. 1,2 It´s estimated that 80-90% of patients with psoriasis will present with nail disorders throughout their lives. 2,3 Studies have shown that nail psoriasis is the causes a significant social problem, often associated with pain. 2 Different therapeutic options can be found for nail psoriasis, which include topical medication, intralesional treatment, systemic therapy, conventional therapies with immunobiological drugs, as well as non-pharmacological treatments. 2,3 Methotrexate (MTX) is a folic acid analogue, responsible for inhibiting the synthesis of deoxyribonucleic acid. 2,3 A literature review shows that intralesional MTX has been successfully used for several indications with no complications reported. The treatment of nail psoriasis has still yielded unsatisfactory results, leading doctors to search for more effective therapeutic approaches. 2 Case 1. We report a 45-year-old female patient with nail dystrophy for 2 years referred for onychomycosis treatment. She presented with exuberant subungual hyperkeratosis and discrete cupuliform depressions, in addition to erythema, periungual edema, and pain in the right hallux (Figure 1). No changes were observed in the other nails. We observed no other alterations on physical examination. Direct mycological examination, repeated weekly for 4 weeks, was always negative. MRI of the hallux confirmed the
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.