Garlic (Allium sativum L.) is a plant with a major economic importance and has medicinal purposes. Garlic due to poor root system has high demands on soil and fertilizer needs. Andosols and Vertisols, the soils in Debre Zeit area in central organic matter and mineral nitrogen. The aim of the study was to determine effect of applying mineral nitrogen, phosphorus, and sulphur fertilizers on growth, yield, yield attributes, and economic returns of the garlic crop o (Andosols and Vertisols). The treatments consisted of three rates of nitrogen (0, 92, 138 kg N ha-1), three rates of phosphorus (0, 40, 80 kg P ha kg S ha-1). Plant growth parameters, including plant height, leaf number, neck diameter and leaf area index were recorded at 30, 60, 90 and 120 days after planting. There were also marked mean bulb weight, bulb diameter, mean clove weight, harvest index and biological yield. From the results of study, was found that the growth, yield and yield attributes of garlic bulbs increased significantly with the increases in the rates of nitrogen, phosphorus, and sulphur and with further increased growth stages of the plant. A significantly yield was obtained from Andosols than Vertisol sulphur significantly influenced the economic returns of garlic on both soil types in addition to the growth and yields of the crop. Based on the obtained application of nitrogen, phosphorus, and sulphur at the rates of 92, 40 and 30 kg ha enhanced production of garlic on both soil types. The results further showed that garlic productivity and profitability was markedly higher on Andosol farmers in the study are could apply 92 kg N ha optimum productivity of the crop for enhanced household income and livelihoods.