The polymerization of acrylic acid (AA) was performed under 60 Co irradiation in the presence of dibenzyl trithiocarbonate at room temperature, and welldefined poly(acrylic acid) (PAA) with a low polydispersity index was successfully prepared. The gel permeation chromatographic and 1 H NMR data showed that this polymerization displays living free-radical polymerization characteristics: a narrow molecular weight distribution (M w /M n ϭ 1.07-1.22), controlled molecular weight, and constant chain-radical concentration during the polymerization. Using PAAOSO C(AS)OSOPAA as an initiator, the extension reaction of PAA with fresh AA was carried out under 60 Co irradiation, and the results indicated that this extension polymerization displayed controlled polymerization behavior.
A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin.
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