A study was designed to identify conditions of frailty in relation to social, demographic, health, cognitive, functional, and psychosocial variables in community-dwelling elderly. The article presents the methodology and preliminary data. A total of 3,478 elderly (65 years and older) were selected from probabilistic samples of seven Brazilian cities chosen by convenience and participated in a data collection session in a community setting. The following characteristics predominated: women (67.7%), married (48%) or widowed (36.4%), living with a son or daughter and family (52.6%), head of family (64.5%), and 1-4 years of schooling (49%); 28.8% were illiterate and 24.8% presented a cognitive deficit; 9.1% were frail, 51.8% pre-frail, and 39.1% non-frail. There were more frail individuals among women, those 80 years or older, the widowed, the illiterate, those who had never attended school, and those with cognitive deficit. In general, the social and demographic data corroborate Brazilian epidemiological studies, while those on frailty, cognitive status, and schooling corroborate the international literature.

A study was designed to identify conditions of frailty in relation to social, demographic, health, cognitive, functional, and psychosocial variables in community-dwelling elderly. The article presents the methodology and preliminary data. A total of 3,478 elderly (65 years and older) were selected from probabilistic samples of seven Brazilian cities chosen by convenience and participated in a data collection session in a community setting. The following characteristics predominated: women (67.7%), married (48%) or widowed (36.4%), living with a son or daughter and family (52.6%), head of family (64.5%), and 1-4 years of schooling (49%); 28.8% were illiterate and 24.8% presented a cognitive deficit; 9.1% were frail, 51.8% pre-frail, and 39.1% non-frail. There were more frail individuals among women, those 80 years or older, the widowed, the illiterate, those who had never attended school, and those with cognitive deficit. In general, the social and demographic data corroborate Brazilian epidemiological studies, while those on frailty, cognitive status, and schooling corroborate the international literature.

ABSTRACT. We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA extraction was performed for -1562C/T genotyping; the plasma was used for MMP-9 quantification. The CT genotype was associated with increased MMP-9 expression (P = 0.0211). High levels of protein, independently of polymorphisms, were observed in the patient group (P < 0.0001) compared to controls. Mucinous tumors with signet ring cells were more frequent in females (P = 0.0177). Overall, patients older than 50 years showed a significant risk of developing CRC (P = 0.0001). MMP- 9 plasma expression was increased in patients with CRC compared to controls, particularly in those with the heterozygous -1562CT genotype.

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ResumoObjetivo: Buscou-se verificar se existe correlação entre o índice de massa corporal, nível de atividade física em METs, coordenação global e equilíbrio estático de idosos da cidade de Ivoti, RS. Materiais e Métodos: estudo descritivo de corte transversal que avaliou 202 idosos, de ambos os gêneros, residentes em Ivoti-RS e selecionados por conveniência. Para as avaliações foram utilizados testes de coordenação global e de equilíbrio, o Questionário Internacional de Atividade Física (IPAQ) formato curto, e calculado o Índice de Massa Corporal segundo os pontos de corte propostos: desnutrição: <22,0 kg/m², eutrofia: de 22,0 a 27,0 kg/m² e obesidade: >27,0 kg/m². O nível de atividade foi classificado em Mets-min/semana como: muito ativo de 1500 a 3000 Mets-min./semana; suficientemente ativo, entre 1499 e 600 Mets-min./ semana e insuficientemente ativo, menos de 600 Mets-min./semana. Os dados foram submetidos à estatística descritiva e correlação de Spearman (α = 0,05), através do programa SPSS, versão 16.0. O estudo foi aprovado pelo CEP da Universidade Feevale, Novo Hamburgo, RS. Resultados: A amostra foi composta por 62 (30,7%) homens e 140 (69,3%) mulheres, idade média masculina de 69,53 ± 6,23 e feminina de 67,52 ± 5,69 anos. A idade média geral da amostra foi de 68,14 ± 5,92 anos. Foram verificadas associações negativas entre as variáveis IMC e coordenação global e IMC e equilíbrio, r= -0,423 ( p<0,01) e r= -0,3060 ( p<0,01) respectivamente. Porém, quando estratificadas por gênero, essas associações não foram significativas nos homens. O nível de atividade física demonstrou correlação negativa com a variável IMC (r= -0,219) e com a idade (r= -0,241); da mesma forma, apresentou correlação positiva com a coordenação motora