Seventy four subjects treated for thyrotoxicosis with radioactive iodine (131I) were studied by means of an ethylenediamine tetra-acetate (EDTA) infusion such as was described by Kaiser & Pensold (1959). The response of these patients to a standard hypocalcaemic insult was followed by means of serum calcium, and in some instances serum inorganic phosphorus, analyses. The treated subjects were separated into euthyroid, hypothyroid and hypothyroid-treated-with-replacement-thyroid-medication groups. These groups were compared to a fourth group of 29 normal subjects. The results suggest that impairment of calcium mobilization was present in the irradiated subjects. However, most of the impairment could be correlated with the presence of hypothyroidism, and no loss of parathyroid reserve seemed indicated by the data.
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