An
integrated catalytic decarboxylation/carboxylation for accessing
isotopically labeled carboxylic acids with 13CO2 or 14CO2 is described. The method shows a
wide scope under mild conditions, even in the context of late-stage
functionalization, and does not require stoichiometric organometallics,
thus complementing existing carbon-labeling techniques en route to
carboxylic acids.
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