IntroductionProlonged sitting and inadequate sleep are a growing concern in society and are associated with impairments to cardiometabolic health and cognitive performance. However, the combined effect of prolonged sitting and inadequate sleep on measures of health and cognitive performance are unknown. In addition, the circadian disruption caused by shiftwork may further impact workers’ cardiometabolic health and cognitive performance. This protocol paper outlines the methodology for exploring the impact of simultaneous exposure to prolonged sitting, sleep restriction and circadian disruption on cardiometabolic and cognitive performance outcomes.Methods and analysisThis between-subjects study will recruit 208 males and females to complete a 7-day in-laboratory experimental protocol (1 Adaptation Day, 5 Experimental Days and 1 Recovery Day). Participants will be allocated to one of eight conditions that include all possible combinations of the following: dayshift or nightshift, sitting or breaking up sitting and 5 hour or 9 hour sleep opportunity. On arrival to the laboratory, participants will be provided with a 9 hour baseline sleep opportunity (22:00 to 07:00) and complete five simulated work shifts (09:00 to 17:30 in the dayshift condition and 22:00 to 06:30 in the nightshift condition) followed by a 9 hour recovery sleep opportunity (22:00 to 07:00). During the work shifts participants in the sitting condition will remain seated, while participants in the breaking up sitting condition will complete 3-min bouts of light-intensity walking every 30 mins on a motorised treadmill. Sleep opportunities will be 9 hour or 5 hour. Primary outcome measures include continuously measured interstitial blood glucose, heart rate and blood pressure, and a cognitive performance and self-perceived capacity testing battery completed five times per shift. Analyses will be conducted using linear mixed models.Ethics and disseminationThe CQUniversity Human Ethics Committee has approved this study (0000021914). All participants who have already completed the protocol have provided informed consent. Study findings will be disseminated via scientific publications and conference presentations.Trial registration detailsThis study has been registered on Australian New Zealand Clinical Trials Registry (12619001516178) and is currently in the pre-results stage.
Sedentary behavior at work contributes to detrimental cognitive outcomes (e.g., decreases in attention). The length of time that cognitive performance benefits are sustained following bouts of breaking up sitting (e.g., using sit-stand desks or walking) is not known. A narrative review of the literature was conducted using a systematic search strategy, with keywords related to breaking up sitting interventions in office-based environments and cognitive performance outcomes in the period immediately post the cessation of the breaking up sitting intervention. Three types of office-based breaking up sitting interventions were identified; 1) sit-stand desks, 2) walking desks and 3) cycling desks. From the eight studies which met the criteria, the impacts of these interventions on cognitive performance outcomes were mixed, with significant benefits in some studies and others reporting no benefit. Of the cognitive domains assessed, working memory, attention, and psychomotor function showed significant sustained improvement for up to 30 minutes post intervention. While there are benefits to a key set of cognitive performance domains following breaking up sitting interventions in office-based settings, no studies have evaluated whether benefits to cognitive performance persist for longer than 30 minutes after the breaking up sitting intervention. Furthermore, specific applications of these cognitive benefits to tasks outside of work (e.g., driving home from work) are unknown.
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