Almost 50 years have passed since ejection fraction (EF), mainly estimated by echocardiography, has been the mainstay of the assessment of left ventricular (LV) systolic function. The prognostic value of EF concerning the outcome and most importantly the survival justifies its critical role in the type of therapy (pharmacological, implantation of devices, or surgical interventions) indicated in different clinical scenarios. More recently, Global Longitudinal Strain (GLS)-deriving from speckle tracking echocardiography-has been developed, and it has provided a more direct assessment of cardiac function, based on the change in length between two points
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