XLIV.-Tlhe Relationship between the Optical Rotatory P d w v s and ths R h t i u e Con$gurcctions of Optically Actice Compounds. The Influence of certain Inorganic Haloids o n the Optical Rotatory P o w e m of a-Hydroxy-acids, a-Amino-acids, and their Dwiv atives.
McKENZIE A N D CLOtTaH : EXPERIMENTS LXXX.-Experiments on the Walclen Inversion. Part 1 I? The Interconversion of the Optically Active Phe~aylmethy~,~lycollic Acids. By ALEX. MCKENZIE and GEORGE WILLIAM CLOUGH. THE carboxylic acids which have so far been investigated from the point of view OF the Walden inversion contain a hydrogen atom in direct attachment to a n asymmetric carbon atom. Work has not been conducted with compounds which do not contain a hydrogen atom directly linked to asymmetric carbon because the number of known optically active hydroxy-acids of this class is very limited. Marckwald and Axelrod (Bey., 1899, 32, 712) oxidised optically active valeric acid t o the corresponding hydroxg-acid, namely, a-hydroxy-ametbylbutyric acid, in the hope of obtaining the latter compound in an active form, but complete racemisation occurred. The same authors have, however, resolved citramalic acid, CO,H*CH,*CMe(OH)*CO,H,
LXXIV.-Il'hc Displacement v f Huloyeii in 1-Phenylchloroacetic ,4cid by Hydroxyand Methoxyyoups. A Contrihtioii to the Chen&ry of the FVa I d e ?~ IrL ue rsion. By ALEX. MCKENZIE and GEORGE: WILLIAM CLOUGH. IN the course of the last few years, the racemising effect of alkali, more particularly during the saponification of optically active menfhyl and bornyl esters, has been repeatedly observed by one of us (Trans.,
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.