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Predictors of psychological distress/adjustment were examined in 25 patients following placement of ICDs. Patients completed a demographic questionnaire and a standardized questionnaire of psychological symptoms (i.e., Symptom Checklist-90 Revised; SCL-90-R). The number of discharges categorized by the patient as inappropriate and appropriate were also ascertained. The number of ICD discharges categorized as inappropriate and diminished levels of physical activity (r = 0.53 and 0.63, P < 0.01, respectively) did significantly relate to overall psychological distress. In addition, after controlling for age and prior psychiatric and physical health status through a stepwise multiple regression analysis, the occurrence of ICD discharges categorized as inappropriate and diminished physical activity continued to significantly predict overall psychological distress (R2 = 0.41, P < 0.01). However, the number of ICD discharges categorized as appropriate did not significantly predict overall psychological distress. The results of this investigation suggest that further refinement of the ICD could reduce the risk of exposure to potential psychological distress, and an analysis of prior and anticipated patient physical activity levels should be a factor when calibrating minimum ICD discharge threshold levels.

We observed high rates of overall and disease specific survival with bladder preservation in patients who achieved a clinically complete response to neoadjuvant chemotherapy. These outcomes support the safety of active surveillance in carefully selected, closely monitored patients with muscle invasive bladder cancer. Future studies should aim to improve patient selection by identifying biomarkers predicting invasive relapse and developing novel imaging methods of early detection.

Science, technology, engineering and mathematics (STEM) policies in the Gulf Arab States are as diverse as the individual economies and political processes that characterize its member states. During the past decade, a number of expert review groups have argued that science and technology policy needs to be reformed and revitalized in the Gulf Arab States. Several reports and studies have identified the need to develop and adopt more rigorous plans to raise the level of research and development (R&D) in the region.In several of the Gulf Arab States, policy makers have sought to address this issue through establishment of new "Education Cities" wherein university campuses have been co-located with industrial parks in order to build regional knowledge economies. Many of these initiatives have attracted foreign talent and global R&D firms. Our research aims to understand the etiology of the under-performance of the R & D efforts in the region. In this paper, we report on results obtained from in-person interviews with the Ministers of Education and other educators in the Gulf Arab States. We interviewed experts in the field of science and technology policy in the Gulf region to address the following major questions: 1) how can science (e.g. biomedical, agriculture, engineering) be strengthened in the Gulf Arab States; 2) how effective are the science policies enacted by regional governments in the Gulf, and how can these policies be enhanced; 3) what role do regional or international collaborations play in a research and training network system, and how can these regional partnerships be bolstered; and, 4) how can the international community assist to accelerate progress and reduce the science knowledge gap. Our results show that the under-performance of the Gulf region in science and technology appears to be due to a: 1) lack of early exposure of young adults to science, 2) low perception of the societal value of science, 3) lack of institutional (e.g. university) resources, 4) too few scientists who make science their long-term careers, 5) lack of an integrated, international research network of collaboration, and 6) lack of motivation among students.We also report on our findings regarding the state-of-the-art of the research enterprise, and the strengths and weaknesses of the research and training environment as perceived by educators/administrators in the region.

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There is emerging evidence identifying microRNAs (miRNAs) as mediators of statin-induced cholesterol efflux, notably through the ATP-binding cassette transporter A1 (ABCA1) in macrophages. The objective of this study was to assess the impact of an HMG-CoA reductase inhibitor, pitavastatin, on macrophage miRNAs in the presence and absence of oxidized-LDL, a hallmark of a pro-atherogenic milieu. Treatment of human THP-1 cells with pitavastatin prevented the oxLDL-mediated suppression of miR-33a, -33b and -758 mRNA in these cells, an effect which was not uniquely attributable to induction of SREBP2. Induction of ABCA1 mRNA and protein by oxLDL was inhibited (30%) by pitavastatin, while oxLDL or pitavastatin alone significantly induced and repressed ABCA1 expression, respectively. These findings are consistent with previous reports in macrophages. miRNA profiling was also performed using a miRNA array. We identified specific miRNAs which were up-regulated (122) and down-regulated (107) in THP-1 cells treated with oxLDL plus pitavastatin versus oxLDL alone, indicating distinct regulatory networks in these cells. Moreover, several of the differentially expressed miRNAs identified are functionally associated with cholesterol trafficking (six miRNAs in cells treated with oxLDL versus oxLDL plus pitavastatin). Our findings indicate that pitavastatin can differentially modulate miRNA in the presence of oxLDL; and, our results provide evidence that the net effect on cholesterol homeostasis is mediated by a network of miRNAs.

The metal phases of seven chondrites and fourteen iron meteorites have been analyzed for gallium by neutron activation. Gallium is quite uniform in the ordinary H-and L-group chondrites and averages 12 ppm. The metal phase of the Abee enstatite chondrite contains 64 ppm Ga. It has previously been established that gallium abundances in iron n•eteorites are distributed around certain unique values. This has been postulated to be related to the origin of iron meteorites. It is noted, however, that there is no correspondence between the gallium group and the cosmic ray exposure age. The abundances of the trace element gallium in iron meteorites has been observed to be distributed into four distinct groups [Goldberg et al., 1951; Lovering et al., 1957], each of which is correlated with the Widmanstatten structure, as follows.

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