Mice were given a single injection of cortisone acetate and killed from one to seven days later.Arterial lesions occurred first and were predominantly located in the right ventricle. Hyalin was present in media of these coronary arteries within 24 hours following administration of cortisone. Exudative and proliferative changes in the arterial walls and perivascular spaces followed medial hyalinization. The highest incidence of arterial lesions (90% ) was attained on the third day following cortisone injection and then decreased slightly (57% ) by the seventh day.Myocardial necrosis was observed first in mice killed 48 hours after receiving cortisone and the incidence did not change significantly thereafter.
Female mice of a Swiss albino stock were fed a high-fat, low-protein, hypolipotropic diet which produces rapid cardiovascular lesions in this stock of mice. Half of the animals were killed after 45 days and the others were placed back on a diet of normal laboratory chow and killed after one, two and three weeks of refeeding.In animals killed after receiving the experimental diet for 45 days small, focal deposits of hyalin in media of large coronary arteries of the right ventricle was the major change.During the first week of recovery (fed a normal diet) the incidence and severity of arterial lesions increased and within individual hearts arteries of all sizes and i n both atria and both ventricles were involved. Following hyalinization an acute arteritis developed that involved all layers of the arterial wall and extended into the perivascular space.After two and three weeks recovery the coronary arteries were characterized by a periarterial fibrosis and by a decrease or absence of the leucocytic reaction. A subendothelial hyperplasia of smooth muscle, arranged longitudinally, was accompanied by an increase in reticular and collagenous fibers. Circular smooth muscle in the media was also hyperplastic.
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